Biochemical Modulation of Skin Reactions
Transdermals, Topicals, Cosmetics
edited by Agis F. Kydonieus

• Presents information that is useful to health-care practitioners, scientists, and formulators in the fields of occupational health, skin care, cosmetics, topical and transdermal drug delivery
• Presents current reviews of the immune function in contact dermatitis, as well as a current review of key cellular and cytokine roles in allergic/irritant dermatitis
• Provides a comprehensive patent literature review of agents affecting irritation and sensitization
• Offers an insightful presentation on future prospects and new technologies that might lead to the reduction or abrogation of skin irritation

Biochemical Modulation of Skin Reactions: Transdermals, Topicals, Cosmetics presents a series of chapters describing technologies and the practical application of biochemicals which might lead to the reduction or abrogation of these skin reaction. In addition, it addresses those areas of skin immunology and skin sciences that account for the processes that control irritant and allergic contact dermatitis and outlines the numerous cellular and molecular factors involved in the development of irritation and sensitization.

Indeed, Biochemical Modulation of Skin Reactions helps serve as a catalyst for further research in the field, allowing for more drugs and cosmetics to be applied to the skin without adverse effects.

Contents

1. Introduction and General Considerations
   1. Fundamental Concepts in Transdermal Delivery of Drugs
   2. The Skin as a Barrier: Structure and Function
   3. Epidermal Lipid Metabolism and Barrier Function of Stratum Corneum
   4. Methods for Testing the Irritation and Sensitization Potential of Drugs and Enhancers
   5. Quantitative Structure Analysis Relationships in the Prediction of Skin Sensitization Potential
   6. Methods for Testing the Phototoxicity and Photosensitization of Drugs

2. Cellular and Humoral Regulation and Pathogenesis
   7. Mechanisms of Allergic and Irritant Contact Dermatitis
   8. The Langerhans Cell: Antigen Processing/Antigen Presentation
   9. The Keratinocyte in Cutaneous Irritation and Sensitization
   10. Pathogenesis of Allergic Contact Dermatitis: Role of T-Cells
   11. The Keratinocyte In Cutaneous Irritation and Sensitization
   12. Mast Cells Regulate Endothelial Cell Function in Inflammation and Repair
   13. Interleukin-1 Receptors and Signal Transduction
   14. Proinflammatory Mediators of the Arachidonic Acid Cascade

3. Biochemical Modulators and Modes of Action
   15. Modulation of Skin Reactions: A General Overview
   16. Glucocorticoids
   17. Ion Channel Modulation of Contact Dermatitis
   18. Mast Cell Degranulating Agents Modulate Skin Immune Responses
   19. Modulation of Neurogenic Inflammation by Strontium
   20. Skin Tolerability of Iontophoresis Treatment
   21. The Effects of Ultraviolet Radiation on the Immune Response
   22. Immune Tolerance and Its Potential to Control Skin Reactions
   23. Future Prospects and Areas of Promising Research

Index

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