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Pharmaceutical Book from C.H.I.P.S.

Bioorganometallics
Biomolecules, Labeling, Medicine
edited by Gerard Jaouen

Bioorganometallics is an excellent source of high quality information for experts in the field.

Features:

  • Details the history of bioorganometallics
  • Covers pharmaceuticals, bioorganometallic chemistry and radiopharmaceuticals

Contents

A Novel Field of Research: Bioorganometallic Chemistry, Origins, and Founding Principles

  • Organometallics and Therapy
  • Toxicology and the Environment
  • Bioanalytical Methods Based on Special Properties of Organometallic Complexes
  • Naturally-occurring Organometallics and Synthetic Models
  • Organometallic Chemistry and Aqueous Solvents

Ruthenium Arene Anticancer Complexes

  • Metal-based Anticancer Complexes
  • Chemistry of Ru Arenes
  • Biological Activity
  • Mechanism of Action

Organometallics Targeted to Specific Biological Sites: the Development of New Therapies

  • Overview of Previous Developments
  • Metal Complex SERMs (Selective Estrogen Receptor Modulators)
  • The Alkyne Cobalt Carbonyl Complexes
  • Ferroquine, a New Weapon in the Fight Against Malaria: the Archetypical Bioorganometallic Approach
  • Other Examples of Organometallics Complexes Tested for their Biological Activities

Radiopharmaceuticals

  • What are Radiopharmaceuticals
  • Organometallic Aquo-ions
  • The Prototype [99Tc(OH2)3(CO)3]+, Synthesis and Properties
  • Combining [99Tc(OH2)3(CO)3]+ with Targeting Vectors

Conjugates of Peptides and PNA with Organometallic Complexes: Syntheses and Applications

  • Conjugates of Organometallics with Small Peptides
  • Conjugates of Organometallics with Natural Peptides
  • Conjugates of Organometallics with PNA

Labeling of Proteins with Organometallic Complexes: Strategies and Applications

  • Redox Probes
  • Luminescent Probes
  • Heavy Metal Probes
  • Metallo–carbonyl Probes for Infrared Spectroscopy

Organometallic Bioprobes

  • The Definition of the Terms Bioprobes and Molecular Bioprobes
  • Response Strategies for the Read-out of Information
  • Organometallic Components for Organometallic Bioprobes – Opening up the Advantages of IR-based Read-out Methods
  • Selectivity of Responses in IR-based Read-out Methods
  • Examples of Organometalcarbonyl Bioprobe Structures
  • Use of Organometallic Bioprobes with Proteins
  • Power of Genetics in the Design of Bioprobe Experiments

Organometallic Complexes as Tracers in Non-isotopic Immunoassay

  • Principle of an Immunoassay
  • Obtaining Specific Antibodies
  • Synthesis of the Organometallic Tracers
  • Examples of Mono- and Multi-metalloimmunoassays (MIA)
  • Use of Organometallic Complexes as Substrates or Co-substrates for Enzyme Immunoassay

Genosensors Based on Metal Complexes

  • Metal Complexes as DNA Probes
  • Electrochemical Analysis of the Interaction of Metal Complexes with dsDNA
  • Gene Detection Based on a Cationic Metal Complex or Metal Complex Conjugated with DNA-binding Ligand
  • Gene Detection Based on Ferrocenyl Oligonucleotides as a Metal Complex Conjugated with DNA Fragments

Supramolecular Host Recognition Processes with Biological Compounds, Organometallic Pharmaceuticals, and Alkali-metal Ions as Guests

  • Host 1
  • A New Host, trans-[Cp*Rh?1-(N3)-1-methylcytosine)(µ-OH)]2(OTf)2
  • Computer Docking Experiments of Organometallic Pharmaceuticals at Estrogen Receptor Binding Sites: Selective, Non-Covalent Interactions with Hormone Proteins
  • Organometallic Ionophores
  • Overall Conclusions for Molecular Recognition

Structure and Mechanism of Metalloenzyme Active Sites

  • Copper
  • Iron
  • Manganese
  • Molybdenum and Tungsten
  • Nickel
  • Zinc

Synthetic Models for Bioorganometallic Reaction Centers

  • Fe-only Hydrogenase
  • NiFe Hydrogenases
  • Acetyl CoA Synthase
  • Anaerobic Carbon Monoxide Dehydrogenase
  • Aerobic Carbon Monoxide Dehydrogenase
  • Methyl Coenzyme M Reductase

Index

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Bioorganometallics
Biomolecules, Labeling, Medicine
edited by Gerard Jaouen

2006 • 480 pages • $199.00 + shipping
Texas residents please add 6.75 % sales tax

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