Biosimulation in Drug Development covers all pharmaceutically relevant topics and provides a comprehensive introduction to this novel and revolutionary tool, presenting both concepts and application examples of biosimulated cells, organs and organisms.

Following an introduction to the role of biosimulation in drug development, the book discusses the simulation of cells and tissues, as well as simulating drug action and effect.

A further section is devoted to simulating networks and populations, and the book concludes with a look at the potential for biosimulation in industrial drug development and for regulatory decisions.

Contents

Introduction

• Simulation in clinical drug development
• Modeling of complex biomedical systems
• Biosimulation of drug metabolism

Simulating Cells and Tissues

• Correlation between in vitro, in situ, and in vivo models
• The glucose-insulin control system
• Biological rhythms in mental disorders
• Energy metabolism in conformational diseases
• Cardiac arrhythmia and full heart simulation
• A framework for whole-body modeling

Tecgnologies for Simulating Drug Action and Effect

• Biochronology II: Circadian drug effects
• Optimising temporal patterns of anticancer drug delivery
• The probability of exocytosis in pancreatic beta-cells
• Modeling kidney pressure and flow regulation
• Toward a computational model of deep brain stimulation in Parkinson's disease
• Constructing the virtual proteasome

Applications of Biosimulation

• Silicon cell models
• Building virtual human populations
• Biosimulation in clinical drug development

Index

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