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Professional Pharmaceutical Reference from C.H.I.P.S.

Calcium Channel Pharmacology

edited by Stefan I. McDonough


Calcium Channel Pharmacology reviews the current ability, future prospects, and physiological and medical significance of being able to distinguish pharmacologically among different calcium channel subtypes.

Chapters are organized around broad concepts addressing the state of the field that naturally cover the pharmacology of each different calcium channel. Mechanistic information on drug-channel interactions is also presented in several chapters, as a theoretical and practical guide to working with calcium channel blockers in general.

Calcium Channel Pharmacology covers the compounds that target individual calcium channel subtypes and the cellular and behavorial functions governed by each different channel. It contains information for basic scientists using calcium channel antagonists as experimental tools, for behavorialists studying animal models of human disease, and for pharmaceutical scientists interested in creating the next generation of calcium channel targeted drugs.

Contents

  1. Introduction
  2. Concepts of State-Dependent Pharmacology of Calcium Channels
  3. Pharmacology of Cav1 (L-Type) Channels
  4. The Therapeutic Utility of Targeting Cav2 Channels
  5. Peptide Toxin Inhibition of Voltage Gated Calcium Channels: Selectivity and Mechanisms
  6. Calcium Channel Blocking Polypeptides: Structure, Function, and Molecular Mimicry
  7. Pharmacology of Cav 3 (T-Type) Channels
  8. Cellular Functions of Calcium Channel Subtypes
  9. Genetic Approaches to the Elucidation of Calcium Channel Functions in Vivo
  10. Calcium Channel Mutations and Associated Diseases
  11. Modulation of High Voltage-Activated Calcium Channels by G Protein-Coupled Receptors
  12. Alternative Splicing in Voltage Gated Calcium Channels

Index

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Calcium Channel Pharmacology
edited by Stefan I. McDonough
2004 418 pages $174.00 + shipping

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