Calreticulin focuses on the latest discoveries on calreticulin, calnexin and other endoplasmic reticulum proteins. Calreticulin has been implicated to affect diverse cellular function and play a role in many pathologies including protein folding disorders, cardiac pathologies, cancer and autoimmunity.

Calreticulin contains contributions from the world leaders in the area of endoplasmic reticulum function, protein folding, Calcium homeostasis and autoimmunity. It raises many intriguing questions about calreticulin, calnexin and the endoplasmic reticulum and gives a unique opportunity to realize the significance of these calcium-binding chaperones. The book is unique in every respect and we are not aware of any other publication focusing on these aspects of endoplasmic reticulum biology.

Calreticulin will attract a diverse audience of cell biologists, biochemists, immunologists, developmental biologists and structural biologists to name a few. Because of a central role of endoplasmic reticulum, calreticulin and calnexin in virtually all cellular functions, this reference should be of interest to everyone in the biological sciences.

Contents

Abbreviations

1. Introduction to Calreticulin
2. Biochemical and Molecular Properties of Calreticulin
3. A Chaperone System for Glycoprotein Folding: The Calnexin/Calreticulin Cycle
4. Calnexin, an ER Integral Membrane Chaperone in Health and Disease
5. Sub-Cellular Distribution of Calreticulin
6. Calnexin and Calreticulin, Molecular Chaperones of the Endoplasmic Reticulum
7. Roles of Calreticulin and Calnexin in Myeloperoxidase Synthesis
8. Calreticulin-Mediated Nuclear Protein Export
9. The Role of Calnexin and Calreticulin in MHC Class I Assembly
10. Calreticulin and the Endoplasmic Reticulum in Plant Cell Biology
11. Modulation of Calcium Homeostasis by the Endoplasmic Reticulum in Health and Disease
12. Calnexin and Calreticulin, ER Associated Modulators of Calcium Transport in the ER
13. ER Calcium annd ER Chaperones: New Players in Apoptosis?
14. Calreticulin in Cytotoxic Lymphocyte-Mediated Cytotoxicity
15. A Role for Calreticulin in the Clearance of Apoptotic Cells and in the Innate Immune System
16. Calreticulin and Tumor Suppression
17. Calreticulin's Role(s) in Autoimmune Disorders
18. Cell Surface Calreticulin: Role in Signaling Thrombospondin Anti-Adhesive Activity
19. Calreticulin Regulation of Lung Endothelial NOS Activity
20. Role of Calreticulin in Leishmania Parasite Secretory
21. The Hookworm Calreticulin Conundrum
22. Calreticulin in C. elegans
23. Calreticulin Deficient Mouse

Appendix I: Human Calreticulin Data Sheet
Appendix II: Amino Acid Sequence of Calreticulin
Index

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