Medical Book from C.H.I.P.S.

Cancer Risk Assessment
Chemical Carcinogenesis, Hazard Evaluation, and Risk Quantification
edited by Ching-Hung Hsu

Cancer Risk Assessment indentifies hazards, determines dose-response relationships, and assesses exposure to characterize the true risk. This book focuses on the quantitative methods for conducting chemical cancer risk assessments for solvents, metals, mixtures, and nanoparticles. It links these to the basic toxicology and biology of cancer, along with the impacts on regulatory guidelines and standards. By providing insightful perspective, Cancer Risk Assessment helps researchers develop a discriminate eye when it comes to interpreting data accurately and separating relevant information from erroneous.


Section 1: Cancer Risk Assessment, Science Policy and Regulatory

  1. Cancer Risk Assessment
  2. Science Policy and Cancer Risk Assessment
  3. Hazard and Risk Assessment of Chemical Carcinogenicity within a Regulatory Context
  4. Use of Cancer Risk Assessments in Determination of Regulatory Standards

Section 2: Cancer Biology and Toxicology

  1. The Interplay of Cancer and Biology
  2. Chemical Carcinogenesis: A Brief History of its Concepts with a Focus on Polycyclic Aromatic Hydrocarbons
  3. Hormesis and Cancer Risks: Issues and Resolution
  4. Thresholds for Genotoxic Carcinogens: Evidence from Mechanism-Based

Section 3: Genetic Toxicology, Testing Guidelines and Regulations and Novel Assays

  1. Development of Genetic Toxicology Testing and its Incorporation into Regulatory Health Effects Test Requirements
  2. Genetic Toxicology Testing Guidelines and Regulations
  3. In Vitro Genetox Assays
  4. In Vivo Genetox Assays and Transgenic mutation models

Section 4: Assessing the Human Relevance of Chemical-Incuced Tumors

  1. Framework Analysis for Determining Mode of Action and Human Relevance
  2. Experimental Animal Studies and Carcinogenicity
  3. Cancer Epidemiology
  4. Rodent Hepatocarcinogenesis
  5. Mode of Action Analysis and Human Relevance of Liver Tumors Induced by PPAR-alpha Activation
  6. Alpha2u-globulin-Nephropathy and Chronic Progressive Nephropathy. as Modes of Action for Renal Tubule Tumour Induction in Rats, and their Possible Interaction
  7. Urinary Tract Calculi and Bladder Tumors

Section 5: Methods for Informing Cancer Risk Quantification

  1. Quantitative Structure-Activity Relationship (QSAR) Analysis of Genotoxic and Nongenotoxic carcinogens: A State-of-the-art overview
  2. Physiologically-Based Pharmacokinetic (PBPK) Models in Cancer Risk Assesment
  3. Omics and Its Role in Cancer Risk Assessment
  4. Computational Toxicology in Cancer Risk Assessment

Section 6: General Approaches for Quantifying Cancer Risks

  1. Linear Low-Dose Extrapolations
  2. Quantitative Cancer Risk Assessment of Nongenotoxic Carcinogens
  3. Nonlinear Low-Dose Extrapolations
  4. Cancer Risk Assessment: More Uncertain than We Thought
  5. Combining Neoplasms for Evaluation of Rodent Carcinogenesis Studies
  6. Cancer Risk Based on an Individual Tumor Type or Summing of Tumors
  7. Exposure Reconstruction and Cancer Risk Estimate Derivation


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Cancer Risk Assessment
Chemical Carcinogenesis, Hazard Evaluation, and Risk Quantification
edited by Ching-Hung Hsu

2010 • 824 pages • $174.00 + shipping
Texas residents please add 6.75 % sales tax

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