Challenges and Opportunities in Translation
edited by Adrian Bot
Cancer Vaccines: Challenges and Opportunities in Translation is the first book in the field to bring immunotherapy treatments from the laboratory trial to the bedside.
Features:
- Critically analyzes the most promising classes of investigational immunotherapies, integrating their scientific rationale and clinical potential
- Discusses “theranostics” as pertaining to immunotherapy, i.e., using molecular diagnostics to identify patients that would most likely benefit from a therapy
- Presents the new paradigm of biomarker guided R&D and clinical development in immunotherapy of cancer
- Reviews bottlenecks in translational process of immunotherapies and offers strategies to resolve them
Contents
- Cancer biology: Meeting the challenge of variability via personalized immunotherapies
- Outlining the gap between preclinical models and clinical situation
- Theranostic” approaches as a strategy to tackle the variability in clinic
- State of the art in active immunotherapies
- Cell based approaches
- Dendritic cell based immunization
- Cancer vaccines based on allogeneic cell lines
- Personalized cancer vaccines
- Antigen based approaches
- Peptide based active immunotherapy in cancer
- Microbial vector approaches
- Prime – boost strategies to immunize against cancer antigens
- Biomarker guided R&D and clinical development
- Predicting responsiveness (theranostic approaches
- Predicting clinical response and evolution
- Predicting toxicities
- Bringing new therapeutics to and through development: Translational medicine in support of active immunotherapies in cancer
- Flexible trial design and bi-directional bedside-lab bench processes as a means to expedite the development of immunotherapies
- Combinatorial approaches as a means to improve on efficacy of cancer vaccines
Index
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