• Surveys the mechanisms of action of carbonic anhydrases
• Presents a comprehensive review of the chemistry of CA inhibitors, including the sulfonamide inhibitors
• Offers the first thorough review of CA activators
• Discusses the connections between carbonic anhydrases and cancer
• Reviews the importance of carbonic anhydrases in gastroenterology, nephrology and neurology

Carbonic Anhydrase: Its Inhibitors and Activators provides a state-of-the-art overview of the latest developments and challenges in carbonic anhydrase research. Authors describe the mechanisms of action of specific inhibitors in relation to physiological function, and present previously unpublished research on CA activators.

Written by a team of internationally recognized experts, this authoritative edition is a leading reference for bioscientists across many disciplines, as well as novices interested in the latest developments in this complex field. An understanding of the mechanisms through which carbonic anhydrases interact with their inhibitors and activators in complex biological environments is essential in developing novel therapeutic agents for the treatment of disease.

Contents

1. Carbonic anhydrases: catalytic and inhibition mechanisms, distribution, and physiological roles
2. Acatalytic CAs: carbonic anhydrase related proteins (CARPs)
3. Multiple binding modes observed in X-ray structures of carbonic anhydrase-inhibitor complexes and elsewhere: consequences for structure-based drug design
4. Development of sulfonamide carbonic anhydrase inhibitors (CAIs)
5. QSAR studies of sulfonamide carbonic anhydrase inhibitors
6. Metal complexes of heterocyclic sulfonamides as carbonic anhydrase inhibitors
7. Non-sulfonamide carbonic anhydrase inhibitors
8. Clinical applications of the carbonic anhydrase inhibitors in ophthalmology
9. Cancer-related CA isozymes and their inhibition
10. Role of carbonic anhydrase and its inhibitors in biological science related to gastroenterology, neurology and nephrology
11. Carbonic anhydrase inhibitors in dermatology
12. Carbonic anhydrase activators

click here to see books • videos • cd-roms of related interest