Carbohydrates play a central role in metabolism, cell-cell recognition, and pathogen defense. To exploit the full potential of this diverse compound class for the development of pharmaceutically active substances, this handbook brings together the latest in carbohydrate chemistry with recent knowledge on the biological function of carbohydrates and their derivatives.

Particular emphasis is placed on carbohydrates with pharmaceutical potential, including the most promising carbohydrate-based therapies currently available.

Carbohydrate-based Drug Discovery is a premier resource for carbohydrate chemists and drug developers, this comprehensive two-volume set contains contributions by more than 80 leading carbohydrate chemists.

Contents

Volume 1

1. Synthetic Methodologies
2. Complex Carbohydrate Synthesis
3. The Chemistry of Sialic Acid
4. Solid-Phase Oligosaccharide Synthesis
5. Solution and Polymer-Supported Synthesis of Carbohydrates
6. Enzymatic Synthesis of Oligosaccharides
7. Glycopeptides and Glycoproteins: Synthetic Chemistry and Biology
8. Synthesis of Complex Carbohydrates: Everninomicin 13,384-1
9. Chemical Synthesis of Asparagine-Linked Glycoprotein Oligosaccharides: Recent Examples
10. Chemistry and Biochemistry of Asparagine-Linked Protein Glycosylation
11. Conformational Analysis of C-Glycosides and Related Compounds: Programming Conformational Profiles of C- and O-Glycosides
12. Synthetic Lipid A Antagonists for Sepsis Treatment
13. Polysialic Acid Vaccines
14. Synthetic Carbohydrate-Based Vaccines
15. Chemsitry, Biochemistry, and Pharmaceutical Potentials of Glycosaminoglycans and Related Saccharides
16. A New Generation of Antithrombotics Based on Synthetic Oligosaccharides

    Volume 2
    

17. Sequencing of Oligosaccharides and Glycoproteins
18. Preparation of Heterocyclic 2-Deoxystreptamine Aminoglycoside Analogues and Characterization of their Interaction with RNAs by Use of Electrospray Ionization Mass Spectrometry
19. Glycosylation Analysis of a Recombinant P-Selectin Antagonist by High-pH Anion-Exchange Chromatography with Pulsed Electrochemical Detection (HPAEC/PED)
20. Analytical Techniques for the Characterization and Sequencing of Glycosaminoglycans
21. Thermodynamic Models of the Multivalency Effect
22. Synthetic Multivalent Carbohydrate Ligands as Effectors or Inhibitors of Biological Processes
23. Glycosyltransferase Inhibitors
24. RNA-Aminoglycoside Interactions
25. Glycosylated Natural Products
26. Novel Enzymatic Mechanisms in the Biosynthesis of Unusual Sugars
27. Neoglycolipids: Identification of Functional Carbohydrate Epitopes
28. A Preamble to Aglycone Reconstruction for Membrane-Presented Glycolipid Mimics
29. Small Molecule Inhibitors of the Sulfotransferases
30. Carbohydrate-Based Treatment of Cancer Metastasis
31. N-Acetylneuraminic Acid Derivatives and Mimetics as Anti-Influenza Agents
32. Modified and Modifying Sugars as a New Tool for the Development of Therapeutic Agents - The Biochemically Engineered N-Acyl Side Chain of Sialic Acid: Biological Implications and Possible Uses in Medicine
33. Modified and Modifying Sugars as a New Tool for the Development of Therapeutic Agents - Glycosidated Phospholipids as a New Type of Antiproliferative Agents
34. Glycoside Primers and Inhibitors of Glycosylation
35. Carbohydrate-Based Drug Discovery in the Battle Against Bacterial Infections: New Opportunities Arising from Programmable One-Pot Oligosaccharide Synthesis

Subject Index

click here to see books • videos • cd-roms of related interest