Carbohydrate-Based Vaccines and Immunotherapies comprehensively reviews the state of this exciting field, offering a single source for both the fundamental science and the latest developments.
Carbohydrate-Based Vaccines and Immunotherapies is an essential reference for organic chemists and biochemists, academic researchers, and other students and professionals involved in vaccine design.
Contents
1. Glycobiology and Immunology
- Glycobiology
- The Immune System
- Carbohydrate Antigens
2. Preparation of Glycoconjugate Vaccines
- Capsular Polysaccharide-Protein Conjugates
- Lipopolysaccharide (LPS) and Lipooligosaccharide (LOS) conjugates
- Total synthetic glycoconjugate vaccines
3. Adjuvants for Protein- and Carbohydrate-Based Vaccines
- Initiation and stimulation of adaptive responses
- "Old" adjuvants and formulations
- Renaissance of innate immunity
- From basic research to practical applications: identification of new adjuvants
- Adjuvants for carbohydrate-based vaccines
- Combinations of adjuvants: preclinical and clinical developments
- Immunomodulation of existing responses: adjuvants for therapeutic vaccines
- Take another route
- Practical aspects of adjuvant development
- Preclinical models used in adjuvant development
4. Carbohydrate-Based Antibacterial Vaccines
- Polysaccharide and glycoconjugate immunobiology
- Deficiencies in the human immune response to polysaccharides
- Glycoconjugate vaccines
- Haemophilus influenzae
- Neisseria meningitidis
- Streptococcus pneumoniae
- Group B Streptococcus
- Salmonella typhi
- Conjugate vaccines- Future concerns
5. Carbohydrate-Based Antiviral Vaccines
- Viral Glycosylation
- Vaccine and Drug Development
6. Carbohydrate-Based Antiparasitic Vaccines
- GPI-based antimalarial vaccine
- LPG-based antileishmanial vaccine
- Other examples
- Perspectives and Future Challenge
7. Carbohydrate-Based Antifungal Vaccines
- Terminology.
- antifungal Glycoconjugate vaccines.
- Antifungal vaccines and the immune system
8. Cancer-Associated and Related Glycosphingolipid Antigens
- Structural Classification of Antigens
- "Abnormal" Expression of Glycosphingolipid (GSL) Glycan Structures in Cancer Tissues
- Discussion of Delected Antigens
- Other Antigens
9. Synthetic Carbohydrate-Based Anticancer Vaccines
- Tumor-Associated Carbohydrate Antigens (TACAs)
- Carbohydrate-Based Cancer Vaccines
- Humoral Immune Response to Carbohydrates
- MHC Mediated Immune Response to Glycopeptides
- Toll-like Receptors and the Link Between Innate and Adaptive Immunity
- Chemical synthesis of tumor-associated carbohydrates and glycopeptides
- Semi-synthetic carbohydrate-based cancer vaccines
- Fully synthetic carbohydrate-based cancer vaccines
- B-epitope and receptor ligand di-epitope constructs
- B- and T-cell di-epitope constructs
- Tri-component vaccines
10. Glycoengineering of Cell Surface Sialic Acid and Its Application to Cancer Immunotherapy
- Engineering of Cell Surface Sialic Acids
- Sialic Acid engineering for Modulation of Cell Surface Reactivity
- Sialic Acids engineering for Cancer Immunotherapy
11. Therapeutic Cancer Vaccines: Clinical Trials and Applications
- Innate and adaptive immunity in relation to cancer immunotherapy
- Design issues for clinical cancer vaccine trials
- Clinical development of cancer vaccines
- Proof of principle trials
- Efficacy Trials
- Clinical endpoints in efficacy trials
- Challenges in vaccine development
- Defining the target tumor-associated antigens
- Production and storage issues
- Clinical trials
12. Carbohydrates as Unique Structures for Disease Diagnosis
- Viruses
- Bacteria
- Fungi
- Parasites
- Autoimmunity
- Tumors
- Inherited or acquired disorders of glycosylation
Index
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