Pharmaceutical Book from C.H.I.P.S.

Carbohydrate-Based Vaccines and Immunotherapies
edited by Zhongwo Guo

Carbohydrate-Based Vaccines and Immunotherapies comprehensively reviews the state of this exciting field, offering a single source for both the fundamental science and the latest developments.

Carbohydrate-Based Vaccines and Immunotherapies is an essential reference for organic chemists and biochemists, academic researchers, and other students and professionals involved in vaccine design.


1. Glycobiology and Immunology

  • Glycobiology
  • The Immune System
  • Carbohydrate Antigens
2. Preparation of Glycoconjugate Vaccines

  • Capsular Polysaccharide-Protein Conjugates
  • Lipopolysaccharide (LPS) and Lipooligosaccharide (LOS) conjugates
  • Total synthetic glycoconjugate vaccines
3. Adjuvants for Protein- and Carbohydrate-Based Vaccines

  • Initiation and stimulation of adaptive responses
  • "Old" adjuvants and formulations
  • Renaissance of innate immunity
  • From basic research to practical applications: identification of new adjuvants
  • Adjuvants for carbohydrate-based vaccines
  • Combinations of adjuvants: preclinical and clinical developments
  • Immunomodulation of existing responses: adjuvants for therapeutic vaccines
  • Take another route
  • Practical aspects of adjuvant development
  • Preclinical models used in adjuvant development
4. Carbohydrate-Based Antibacterial Vaccines

  • Polysaccharide and glycoconjugate immunobiology
  • Deficiencies in the human immune response to polysaccharides
  • Glycoconjugate vaccines
  • Haemophilus influenzae
  • Neisseria meningitidis
  • Streptococcus pneumoniae
  • Group B Streptococcus
  • Salmonella typhi
  • Conjugate vaccines- Future concerns
5. Carbohydrate-Based Antiviral Vaccines

  • Viral Glycosylation
  • Vaccine and Drug Development
6. Carbohydrate-Based Antiparasitic Vaccines

  • GPI-based antimalarial vaccine
  • LPG-based antileishmanial vaccine
  • Other examples
  • Perspectives and Future Challenge
7. Carbohydrate-Based Antifungal Vaccines

  • Terminology.
  • antifungal Glycoconjugate vaccines.
  • Antifungal vaccines and the immune system
8. Cancer-Associated and Related Glycosphingolipid Antigens

  • Structural Classification of Antigens
  • "Abnormal" Expression of Glycosphingolipid (GSL) Glycan Structures in Cancer Tissues
  • Discussion of Delected Antigens
  • Other Antigens
9. Synthetic Carbohydrate-Based Anticancer Vaccines

  • Tumor-Associated Carbohydrate Antigens (TACAs)
  • Carbohydrate-Based Cancer Vaccines
  • Humoral Immune Response to Carbohydrates
  • MHC Mediated Immune Response to Glycopeptides
  • Toll-like Receptors and the Link Between Innate and Adaptive Immunity
  • Chemical synthesis of tumor-associated carbohydrates and glycopeptides
  • Semi-synthetic carbohydrate-based cancer vaccines
  • Fully synthetic carbohydrate-based cancer vaccines
  • B-epitope and receptor ligand di-epitope constructs
  • B- and T-cell di-epitope constructs
  • Tri-component vaccines
10. Glycoengineering of Cell Surface Sialic Acid and Its Application to Cancer Immunotherapy

  • Engineering of Cell Surface Sialic Acids
  • Sialic Acid engineering for Modulation of Cell Surface Reactivity
  • Sialic Acids engineering for Cancer Immunotherapy
11. Therapeutic Cancer Vaccines: Clinical Trials and Applications

  • Innate and adaptive immunity in relation to cancer immunotherapy
  • Design issues for clinical cancer vaccine trials
  • Clinical development of cancer vaccines
  • Proof of principle trials
  • Efficacy Trials
  • Clinical endpoints in efficacy trials
  • Challenges in vaccine development
  • Defining the target tumor-associated antigens
  • Production and storage issues
  • Clinical trials
12. Carbohydrates as Unique Structures for Disease Diagnosis

  • Viruses
  • Bacteria
  • Fungi
  • Parasites
  • Autoimmunity
  • Tumors
  • Inherited or acquired disorders of glycosylation


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Carbohydrate-Based Vaccines and Immunotherapies
edited by Zhongwu Guo
2009 408 pages $116.95 + shipping
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