Cardiovascular Development and Congenital Malformations brings together the leading scientists from around the world who are actively engaged in studies of the etiology, morphogenesis and physiology of congenital cardiovascular diseases.

Cardiovascular Development and Congenital Malformations is divided into distinct categories, each focusing on a particular aspect of cardiovascular development.

Contents

Establishing Left-Right Patterning and Cardiac Looping

1. Microenvironment provides left–right instructions to migrating precardiac mesoderm
2. Calmodulin- inv protein interaction and left-right determination
3. Misexpression of upstream laterality genes on downstream mechanisms of heart looping: A flectin perspective
4. Pleiotropic effects of Pitx2 isoform c on morphogenesis in the mammalian heart
5. Signal transductions during cardiac myofibrillogenesis and looping
6. Biological role of fibulin-2 in cardiovascular development

Mechanisms of Cardiogenesis and Myocardial Development

7. TBX5 regulates cardiac cell behavior during cardiogenesis
8. Cardiac homeobox protein Csx/Nkx2-5and its associated proteins
9. Regulation of myocardium formation after the initial development of the linear heart tube
10. The Role of the extracellular matrix (ECM) in cardiac development
11. Teratogenic effects of bis-diamine on the developing myocardium
12. Proliferative responses to myocardial remodeling in the developing heart

Formation of Endocardial Cushions and Valves

13. TGFâ signaling during atrioventricular cushion transformation
14. The endocardium as a unique modulator of in utero cardiovascular form and function
15. Valvulogenesis: Role of periostin in cushion tissue differentiation
16. Role of Fibroblast growth factors in early valve leaflet formation
17. Msx1 expression during chick heart development: possible role in endothelial-mesenchymal transformation during cushion tissue formation

Segment and Chamber Specification

18. Tbx5 specifies the left/right ventricles and ventricular septum position during cardiogenesis
19. Transciptional regulation of ventricular morphogenesis
20. Fgf10 and the embryological origin of outflow tract myocardium
21. Evolutionary conservation of atrial natriuretic factor (Anf) expression, cardiac chamber formation and the heart-forming region

Formation of Specialized Conduction Tissues

22. Induction and Patterning of the Impulse Conducting Purkinje Fiber Network
23. Spatial Correlation of Conduction Tissue in the Ventricular Trabeculae of the Developing Zebrafish
24. Development of the cardiac conduction system and contribution of neural crest and epicardially derived cells
25. The Development of the Cardiac Conduction System: an old story with a new perspective
26. The role of calreticulin in cardiac development and function

Coronary Artery Development

27. Development of proximal coronary artery in quail embryonic heart
28. Possible roles of the extracellular matrix in coronary vasculogenesis of mouse
29. Abnormal coronary development in bis-diamine treated embryo

Models of Congenital Cardiovascular Malformations

30. Deciphering the basis for congenital heart defects using a mouse model of Holt-Oram syndrome
31. The role of the transcriptional co-repressor FOG-2 in cardiac development
32. Molecular mechanisms regulating tissue-specific expression of Tbx1
33. Tbx1 and DiGeorge syndrome: A genetic link between cardiovascular and pharyngeal development
34. New insights into the role of Tbx1 in the DiGeorge mouse model

Role of Neural Crest Cells in Cardiovascular Development

Chapters 35-38

Formation of Outflow Tracts

Chapters 39-40

Imaging Techniques

Chapter 41

Cardiovascular Physiology During Development

Chapters 42-50

Patent Ductus Arteriosus

Chapters 51-54

Human Clinical Genetics and Epidemiology

Chapters 55-70

Index

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