Cardiovascular Effects of Inhaled Ultrafine and Nano-Sized Particles assists scientists, toxicologists, clinicians, and public health regulators to understand the complex issues that determine the impact of air pollution on the cardiovascular system.

The book covers a range of relevant topics including:

• particulate matter (PM) sources and characterization
• methods of exposure
• impact of PM on cells and systems
• role of particles in the pathophysiology of cardiovascular disease
• risk assessment
• potential environmental and therapeutic interventions

Contents

Part I: Issue Framing

1. Overview
2. Acute Effects of particulate Matter on the Risk of Myocardial Infarction
3. Chronic Effects of Air Pollution on Cardiovascular Health

Part II: Exposure

4. Particle Characterization
5. Exposure Assessment for Ambient Ultrafine Particles
6. From Exposure to Dose
7. Translocation of Inhaled Nanoparticles
8. Role of Chemical Compossition in Determining the Cardiovascular Effects of Particles

Part III: Methodology

9. In Vitro Studies
10. Experimental Studies in Animals
11. Human Exposure Studies
12. Panel Studies

Part IV: Particles and Cardiovastular Disease: Mechanisms

A. Atherogenesis

13. Particulates and Oxidative Stress
14. Role of Inflammation in the Atherogenic Effects of Particulate Matter
15. Inhaled Particles, Postprandial Lipids, and Their Possible Contribution to Atherogenesis: The Trojan Horse Hypothesis
16. Inhaled Particulate Matter and Atherosclerosis in Humans
17. Effects of nanoparticles on the Pulmonary Vasculature
18. Particulate Matter, Hypertension, and the Metabolic Syndrome
19. Particles and the Vascular Endothelium

B. Vascular Dysfunction

C. Thrombosis

20. Particles, Coagulation, and Thrombosis
21. Particles and the Pathogenesis of Atherothrombosis

D. Arrhythmia

22. Particles and the Autonomic Nervous System
23. Air Pollution and Arrhythmia

Part V: Environmental and Public Health Policy

24. Risk Assessment
25. Environmental Regulation of Particulate Matter
26. From Ambient Altrafine Particles to Nanotechnology and Nanotoxicology

Index

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