Catalytic Antibodies
edited by Ehud Keinan

Here, the pioneers in the use of catalytic antibodies review the entire scope of this interdisciplinary field, covering such topics as:

• Theoretical aspects of structure, mechanism and kinetics
• Practical considerations, from immunization techniques to screening methods
• In vitro evolution and other modern approaches
• Applications from organic synthesis to medical uses.

Backed by the leading authorities in antibody catalysis, this is the first book to provide such comprehensive coverage and will be the prime reference for biochemists, organic chemists, biotechnologists and biomedical researchers.

Contents

1. Immunological Evolution of Catalysis
2. Critical Analysis of Antibody Catalysis
3. Theoretical Studies of Antibody Catalysis
4. The Enterprise of Catalytic Antibodies: A Historical Perspective
5. Catalytic Antibodies in Natural Products Synthesis
6. Structure and Function of Catalytic Antibodies
7. Antibody Catalysis of Disfavored Chemical Reactions
8. Screening Methods for Catalytic Antibodies
9. In vitro Evolution of Catalytic Antibodies and Other Proteins via Combinatorial Libraries
10. Medicinal Potential of Catalytic Antibodies
11. Reactive Immunization: A Unique Approach to Aldolase Antibodies
12. The Antibody-Catalyzed Water Oxidation Pathway
13. Photoenzymes and Photoabzymes
14. Selectivity with Catalytic Antibodies – What Can Be Achieved?
15. Catalytic Antibodies as Mechanistic and Structural Models of Hydrolytic Enzymes
16. Transition State Analogs – Archetype Antigens for Catalytic Antibody Generation
17. Polyclonal Catalytic Antibodies
18. Production of Monoclonal Catalytic Antibodies: Principles and Practice
19. Natural Catalytic Antibodies – Abzymes

Index

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