Cell-Cycle Mechanismsand Neuronal Cell Death examines the role of cell cycle activation in the molecular mechanisms leading to neuronal degeneration.

Cell-Cycle Mechanismsand Neuronal Cell Death serves to gain new insights into the molecular determinants of neuronal death and to establish new targets for therapeutic intervention.

Contents

1. Cell Cycle Activation in Neurons: The Final Exit of Brain-Morpho-Dysregulation

• Selective Neuronal Vulnerability: The Key Issue to Understand Neurodegenerative Disorders
• Plasticity Meets Cell Death
• Brain-Morpho-Dysregulation and Replay of Developmental Mechanisms
• The Cell Cycle Integrates Intercellular and Intercellular Signaling and Links Development, Oncogenesis and Neurodegeneration

2. Paved with Good Intentions: The Link Between Cell Cycle and Cell Death in the Mammalian Central Nervous System

• Cell Division
• Cell Cycle Events in the Cell Death Process
• The Cell Biology of Cell Cycle Induced Cell Death
• Human Disease

3. The Role of Presenilins in the Cell Cycle and Apoptosis

• Alzheimer's Disease Pathology
• Presenilin Structure and Function
• The Role of Presenilins in Apoptosis
• Presenilins Apoptosis and the Calcium Connection
• Presenilins and the Cell Cycle
• Do Presenilin Genes Have Dual Functions in Cellular Proliferation and Aging?
• Apoptosis and Alzheimer's Disease

4. Cell Cycle Activation and Cell Death in the Nervous System

• Cell Cycle and Apoptosis in the Developing Nervous System
• Iatrogenic Neurodegeneration
• Neurodegenerative Disorders
• Alzheimer's Disease and Related Dementias
• Temporal Lobe Epilepsy
• A Few Words of Caution

5. Cell Cycle and Chromosome Segregation Defects in Alzheimer's Disease

• Trisomy 21 Mosaicism in Alzheimer's Disease
• Defects in Mitosis in Alzheimer's Disease
• Potential Mitotic Function of the Presenilin Proteins
• Nucleoplasm or Cytoplasm
• Lumen of Nuclear Envelope or Endoplasmic Reticulum
• Mitotic Effects of the Normal and FAD Mutant Presenilin Transgenic and Knockout Mice
• Mutation/Inactivation of the Tumor Suppressor
• Causes Chromosome Instability and Regulates Expression of Presenilin

6. Alzheimer Disease: A New Beginning or a Final Exit?

• Pathological Hallmarks of Alzheimer Disease
• A Mitotic Phenotype Appears in Alzheimer Disease
• G₀ Exit, G₁ Entry, and Mitogenic Drivers in Alzheimer Disease
• Apoptotic Avoidance in Alzheimer Disease
• Redox Imbalance and Cell Cycle Re-Entry

7. From Cell Cycle Activation to the Inhibition of the Wnt Pathway: A Hypothesis of How Neurons Die in Response to β-Amyloid

• The Regulation of the Cell Cycle by Aβ in Adult Neurons
• Cell Cycle Signaling, DNA Damage and Neuronal Apoptosis
• Pharmacological Perspectives

Index

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ORDER NOW Cell-Cycle Mechanisms and Neuronal Cell Death by Agata Copani 2005 • 102 pages • $128.95 + shipping Texas residents please add 6.75% sales tax