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Pharmaceutical Book from C.H.I.P.S.

Cell Culture Technology for Pharmaceutical and Cell Based Therapies
edtied by Sadettin Ozturk

Cell Culture Technology for Pharmaceutical and Cell Based Therapies discusses aspects of cell biology and biochemical engineering used in pharmaceutical process development and manufacturing.

Features:

  • Describes manipulations and the genetic engineering of cells for the production of biotechnology products
  • Outlines novel techniques for the development of serum-free and chemically defined media formulations
  • Addresses glycosylation and post translation of proteins and their importance for product quality
  • Presents guidelines for upstream and downstream process development for the production of cell culture based pharmaceuticals
  • Offers detailed guidance on the operation of bioreactors and production facility design
  • Presents a comprehensive outline for drug formulation
  • Describes the design of aeration, mixing, and process control for batch and perfusion bioreactors
  • Details the optimization of protein expression from transient, batch, and perfusion systems
  • Offers discussions on the use of mammalian cells, insect cells, and stem cells
  • Discusses the emerging field of tissue engineering and its applications in the development of cell based therapies

Contents

  • Cell Culture Technology: An Overview
  • Recombinant DNA Technology and Cell Line Development
  • Medium Development
  • Cell Metabolism
  • Protein Glycosylation
  • Cell Culture Bioreactors
  • Aeration, Mixing and Hydrodynamics in Bioreactors
  • Instrumentation and Process Control
  • Cell Culture Kinetics and Modeling
  • Fed-Batch Cultivation Of Mammalian Cells For Production Of Recombinant Proteins
  • Optimization of High Density Perfusion Bioreactors
  • Cell Separation And Product Capture
  • Downstream Processing
  • Formulation, Finishing, and Packaging
  • Validation Of Cell Culture Based Processes & Qualification Of Associated Equipment And Facility
  • Facility Design
  • Transient Expression of Proteins
  • Large-Scale Propagation of Insect Cells
  • Advances In Adult Stem Cell Culture
  • Ex Vivo Culture Of Hematopoietic And Mesenchymal Stem Cells For Tissue Engineering And Cell-Based Therapies

Index

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Cell Culture Technology for Pharmaceutical and Cell Based Therapies
edtied by Sadettin Ozturk
2005 776 pages $188.95 + shipping
Texas residents please add 6.75 % sales tax

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