Chemistry and Pharmacology of Anticancer Drugs is a comprehensive survey of all families of anticancer agents currently in use or in advanced stages of clinical trials, including biologicals.

Features:

• Summarizes the fundamental causes of cancer, modes of treatment, and the philosophy of cancer drug discovery
• Brings together a broad spectrum of information relating to the chemistry and pharmacology of anticancer drugs and therapies
• Covers all types of anticancer drugs including biological agents and many in the research, development, and clinical evaluation stages
• Provides molecular structures and generic/trade names for each agent, along with information on chemistry, mechanism of action, and side effects/dose scheduling where appropriate
• Introduces cutting-edge research methodologies and tools being used to discover and develop new anticancer drugs and therapies
• Describes the new areas of oncogenomics and chemoprevention

Contents

Introduction to Cancer

• Metastases
• Diagnosis and Screening
• Formation of Cancer Cells (Tumorigenesis)
• Mechanisms of Genomic Damage
• Treatments
• Discovery of Anticancer Drugs and Preclinical Evaluation
• Accessibility of Drugs to Tumor Cells
• Achieving Selective Toxicity
• Limiting the Toxicity of Chemotherapeutic Agents
• Overview of Mechanisms of Action of Chemotherapeutic Agents
• Drug Resistance
• Combination Chemotherapy
• Use of Adjuvants
• Infertility Following Cancer Treatments

Antimetabolites

• DHFR Inhibitors (Antifolates)
• Purine Antimetabolites
• Pyrimidine Antimetabolites
• Thymidylate Synthase Inhibition
• Adenosine Deaminase Inhibition
• Ribonucleotide Reductase Inhibition

DNA Interactive Agents

• Alkylating Agents
• Cross-Linking Agents
• Intercalating Agents
• Topoisomerase Inhibitors
• DNA-Cleaving Agents

Antitubulin Agents

• Vinca Alkaloids
• The Taxanes

Molecularly Targeted Agents

• Kinase Inhibitors
• Inhibition of Ras Pathway Signaling
• Cell Cycle Inhibitors
• Proteasome Inhibitors
• mTOR Inhibitors

Hormonal Therapies

• Breast Cancer
• Prostatic Cancer
• Neuroendocrine Tumors: Somatostatin Analogs
• Estrogen Therapy
• Progestogen Therapy

Tumor-Targeting Strategies

• Antibody-Based Approaches
• Vascular-Targeting Strategies
• X-DEPT (Biphasic) Strategies
• Enzymatic Targeting
• Photoactivated Drugs (Photodynamic Therapy)
• Boron Neutron Capture Therapy
• Novel Drug Delivery Approaches

Biological Agents

• Biological Response Modifiers
• Immunotherapy
• Enzyme-Based Therapies
• Vaccines

The Future

• Novel Biological Targets and Therapeutic Strategies
• New Research Tools and Methodologies
• Chemopreventive Agents

Personalized Treatments

• Screening for Risk of Disease Development
• Prognosis and Staging
• Screening for Risk of Recurrence of Disease
• Selecting Best Treatments for Patients
• Predicting Side Effects of Chemotherapeutic Agents
• Pharmacogenomics in Clinical Trials

Adjunct Therapies

• Anti-emetic Agents
• Steroidal Agents
• Adjuvent Enzymes

Index

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