Centrosomes in Development
and Disease
edited by Erich A. Nigg

This book summarizes our current knowledge of the structure, function and evolution of centrosomes and related microtubule-organizing centres.

Reflecting recent discoveries and ongoing research, it emphasizes the role of centrosomes in development and disease, with a particular focus on cancer.

Contents

1. Microtubule Organization and Dynamics
   1. Early Studies on Centrioles and Centrosomes
   2. The Tubulin Superfamily
   3. Microtubule Nucleation
   4. The Budding Yeast Spindle Pole Body: A Centrosome Analog
   5. Dissection of Basal Body and Centriole Function in the Unicellular Green Alga Chlamydomonas reinhardtii
   6. The Centrosome in Evolution

2. The Integration of Centrosome and Chromosome Cycles
   7. A Proteomic Approach to the Inventory of the Human Centrosome
   8. The Role of the Centrosome in Cell Cycle Progression
   9. Centrosome Duplication and its Regulation in the Higher Animal Cell
   10. A Synergy of Technologies: Using Green Fluorescent Protein Tagging and Laser Microsurgery to Study Centrosome Function and Duplication in Vertebrates
   11. Centrosome Regulation in Response to Environmental and Genotoxic Stress

3. The Centrosome in Development and Tissue Architecture
   12. The C. elegans Centrosome during Early Embryonic Development
   13. Centrosomes in a Developing Organism: Lessons from Drosophila
   14. Centrosome Inheritance during Human Fertilization and "Therapeutic" Cloning: Reproductive and Developmental Diseases and Disorders Caused by Centrosome Dysfunction
   15. Microtubule Organizing Centers in Polarized Epithelial Cells

4. Centrosomes in Disease
   16. Centrosome Anomalies in Cancer: From Early Observations to Animal Models
   17. Radiation Therapy and Centrosome Anomalies in Pancreatic Cancer
   18. Human Papillomavirus Infection and Centrosome Anomalies in Cervical Cancer
   19. Manipulation of Centrosomes and the Microtubule Cytoskeleton during Infection by Intracellular Pathogens
   20. Basal Bodies and Microtubule Organization in Pathogenic Protozoa

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