Chemistry and Biochemistry of B₁₂
edited by Ruma Banerjee

There have been dramatic advances in the field of researching Vitamin B₁₂, and those advances have served to revitalize interest in Vitamin B₁₂ among biochemists, organic and inorganic chemists, microbiologists, structural biologists, and many other science professions.

This book offers one major reference work that unites all of the vital discoveries about Vitamin B₁₂, and its numerous essential functions.

Contents

1. Chemistry of B₁₂
   1. B₁₂ History
   2. X-ray Crystallography of B₁₂
   3. X-Ray Absorption Spectorscopy of B₁₂: Structural Changes of Intermediate States
   4. Electronic Structure and Spectra of B₁₂: From Trans Effects to Protein Conformation I
   5. Electronic Structure and Spectra of B₁₂: From Trans Effects to Protein Conformation II
   6. EPR Spectroscopy of B₁₂-Dependent Enzymes
   7. NMR Spectroscopy of B₁₂
   8. Vibrational Spectroscopy of B₁₂ and Related Compounds
   9. Magnetic Field Dependence of Cobalamin Photochemistry and Enzymes
   10. Stereospecificity of the Coenzyme B₁₂ Catalyzed Rearrangements and the Role of Negative Catalysis
   11. Modeling the Structure of Cobalt Corrins by Molecular Mechanics and Molecular Dynamics Methods
   12. B₁₂ Electrochemistry and Organometallic Electrochemical Synthesis

2. Biochemistry and Biology of B₁₂
   13. B₁₂ and Nutrition
   14. Inborn Errors of Cobalamin Metabolism
   15. Diagnostic and Therapeutic Analogs of Cobalamin
   16. Intrinsic Factor and Haptocorrin and Their Receptors
   17. Transcobalamin II
   18. Mammalian Receptors of Vitamin B₁₂-Binding Proteins
   19. Cobalamin Transport in Bacteria
   20. Biosynthesis of B₁₂ in the Aerobic Organism Pseudomonas denitrificans
   21. B₁₂ Biosynthesis: The Anaerobic Pathway
   22. Biosynthesis of the 5-6 Dimethylbenzimidazole Moiety of Cobalamin and of the Other Bases Found in Natural Corrinoids
   23. Regulation of Adenosylcobalamin Biosynthesis in Salmonella typhimurium
   24. X-ray Crystallography of B₁₂ Enzymes: Methylmalonyl-CoA Mutase and Methionine Synthase
   25. The Acetogenic Corriniod Proteins
   26. The Role of Corrinoids in Methanogenesis
   27. Methionine Synthase
   28. Methylmalonyl-CoA Mutase
   29. Ribonucleotide Reductases
   30. Glutamate Mutase and 2-Methyleneglutarate Mutase
   31. Diol Dehydrase and Glycerol Dehydrase
   32. Ethanolamine Ammonia-Lyase
   33. Anomutases
   34. Isobutyryl-CoA Mutase
   35. Reductive Dehalogenases

Index

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