Chemokine Receptors as Drug Targets provides an understanding of the full spectrum of chemokine receptor biology, recent and historical progress towards receptor inhibitors, and insights and perspectives for future research directions.

Opening with a general introduction on chemokine function and chemokine receptor biology, the handbook goes on to cover the known implications of these signaling molecules in human diseases, such as cancer, neural disorders, and viral infection, including HIV/AIDS.

The second half of the book systematically surveys current drug development efforts at targeting individual chemokine receptors, as well as other chemokine interaction partners. Contributions in the first part of the book are mainly from academia, whereas the second part contains up-to-date reports from the pharmaceutical industry.

Contents

Part One Fundamentals of Chemokines and Chemokine Receptors

1. Structural Aspects of Chemokines and their Interactions with Receptors and Glycosaminoglycans
2. Structural Insights for Homology Modeling of Chemokine Receptors
3. Signaling Events Involved in Chemokine-Directed T Lymphocyte Migration
4. The Atypical Chemokine Receptors
5. Targeting Chemokine Receptor Dimers: Are there Two (or More) to Tango?

Part Two Chemokine Receptors in Disease

6. Chemokine Receptors in Inflammatory Diseases
7. Chemokines and their Receptors in Central Nervous System Disease
8. Chemokines and Cancer Metastasis
9. Constitutively Active Viral Chemokine Receptors: Tools for Immune Subversion and Pathogenesis
10. CCR5 Antagonists in HIV
11. CXCR4 as a Therapeutic Target
12. Low Molecular Weight CXCR2 Antagonists as Promising Therapeutics
13. Therapeutic Targeting of the CXCR3 Receptor
14. Targeting CCR1
15. Targeting CCR3
16. Chemokine Binding Proteins as Therapeutics

    Index

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