Features

• The history of Cisplatin
• Describes the current clinical status of platinum-derived antitumor agents
• The biochemistry of cisplatin and current views of its mode of action
• Focuses on the chemistry relevant to interactions of platinum(II) species with biomolecules
• The examples compiled elucidate the impact of cisplatin on specific fields within inorganic chemistry, from the ‘platinum blues’ to platinum(III) compounds
• Description of several new developments in the field

Cisplatin - Chemistry and Biochemistry of a Leading Anticancer Drug compiles, in six parts, the various aspects of chemistry, biochemistry, biology, pharmacology, and medicine relevant to cisplatin, describing new links that suggest how cisplatin may trigger a cascade of cellular events that result ultimately in apoptosis. This volume provides all scientists, from coordination chemists to oncologists, with a unique resource detailing the state-of-the-art and future research perspectives, together with the fascinating story, of cisplatin.

Contents

1. THE START
   
   • Platinum Complexes for the Treatment of Cancer: Why the Search Goes On.

2. CISPLATIN - HOW GOOD IS IT?
   
   • Clinical Status of Cisplatin and Other PT Antitumor Drugs.

3. HOW DOES IT POSSIBLY? -BIOCHEMISTRY
   
   • The Response of Cellular Proteins to Cisplatin - Damaged DNA.
   • The Mechanism of Action of Cisplatin: From Adducts to Apoptosis.
   • Replication of Platinated DNA and its Mutagenic Consequences.
   • Interstand Cross-Links in Cisplatin- or Transplatin- Modified DNA.

4. CHEMISTRY RELEVANT TO PT-BIOMOLECULE INTERACTIONS
   
   • Platinum Complexes: Hydrolysis and Binding to N7 and N1 of Purines.
   • Reactivity and Inertness of Pt-Nucleobase Complexes.
   • Kinetics and Selectivity of DNA Platination.
   • Structure and Dynamics of PT Anticancer Drug Adducts from Nucleotides to Oligonucleotides as Revealed by NMR Methods.
   • 195Pt and 15N NMR Spectroscopic Studies of Cisplatin Reactions with Biomolecules.
   • Structural Aspects of PT-Purine Interactions: From Models to DNA.
   • Platinum-Sulfur Interactions Involved in Antitumor Drugs, Rescue Agents and Biomolecules.
   • Diammine- and Diamineplatinum Complexes with Non-Sulfur-Containing Amino Acids and Peptides.

5. INORGANIC CHEMISTRY REVIVED OR INITIATED BY CISPLATIN
   
   • Platinum Blues: On the Way Toward Unraveling a Mystery.
   • Heteronuclear PT(II) Complexes with Pyrimidine Nucleobases.
   • Displatinum(III) Complexes: Chemical Species more Widely Spread than Suspected.
   • Inorganic and Organometallic Chemistry of Cisplatin-Derived PT(III) Complexes.

6. NEW DEVELOPMENTS
   
   • Structure-Activity Relationships with Di- and Trinuclear Platinum Phase I Clinical Anticancer Agents.
   • The Development of Orally-active Platinum Drugs.
   • Methods for Screening the Potential Antitumor Activity of Platinum Compounds in Combinatorial Libraries.
   • Computational Studies on Platinum Antitumor Complexes and their Adducts with Nucleid Acids Constituents.

Index

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