Clinical Diabetes Research provides summaries of established state-of-the art-techniques and introduces the new technologies, evaluating their potential in clinical diabetes research.

Clinical Diabetes Research is of great relevance for researchers (from students and post-docs to principal investigators) in the field of human metabolism, clinical endocrinologists and diabetologists who are involved in clinical studies.

Contents

1. Basics of Clinical Metabolic Research
2. Methods for the Assessment of b-Cell Function In Vivo
3. Assessment of Insulin Sensitivity from Steady-State and Dynamic Tests
4. Glucose Clamp Techniques
5. Methods of Assessment of Counterregulation to Hypoglycaemia
6. Glucose Kinetics: Measurement of Flux Rates
7. Xenobiotics as Probes of Carbohydrate Metabolism
8. Tracing Hepatic Glucose and Glycogen Fluxes with 2H2O
9. Lipid Kinetics
10. Protein and Amino Acid Kinetics
11. Assessment of Metabolic Fluxes by In Vivo MR Spectroscopy
12. Positron Emission Tomography in Metabolic Research
13. Assessment of Body Fat Content and Distribution
14. Tissue Biopsies in Diabetes Research
15. Assessment of Vascular Function
16. Cardiovascular Autonomic Function Testing
17. Nerve Function Testing
18. Kidney Function
19. Techniques for the Investigation of the Eye in Diabetes
20. Basics of Molecular Genetics: Lessons from Type 2 Diabetes
21. Good Clinical Practice: Friend or Foe
22. Statistical Considerations in Diabetes Trials

Index

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