Clinical Pharmacokinetics is a guide to the use of pharmacokinetic principles in routine clinical practice.

Contents

Basic Pharmacokinetics

• Rates of Reaction
• Pharmacokinetic Models
• Pharmacokinetic Parameters
• Pharmacokinetic Applications

Therapeutic Drug Monitoring

• TDM - Which Drugs and Why?
• Education and Training
• Interpretation of Serum Drug Levels
• Free Drug Concentration Monitoring
• Use of Calculators and Computer Software Packages

Clinical Pharmacokinetics in Renal Impairment

• Assessment of Renal Function
• Altered Pharamcokinetics
• Absorption and Bioavailability
• Distribution
• Metabolism
• Excretion
• Approaches to Drug Dose Alteration in Renal Impairment
• Maintenance Dose
• Loading Dose
• Dialysis
• Loading Doses of Drugs
• Administration of Maintenance Doses in Renal Replacement Therapy

The Effect of Liver Dysfunction on Pharmacokinetics

• Pharmacokinetic Parameters
• Model Drugs Used as Indicators of Changed Drug Clearance

Clinical Pharmacokinetics in the Elderly

• Absorption
• Distribution
• Metabolism
• Elimination
• Other Factors

Aminoglycosides

• Therapeutic Range and Evidence-Base
• Pharmacokinetic Profile (ADME)
• Population Data
• Equation Resource - Which Equations to Use and When
• Reasons for Request
• Factors Affecting Therapeutic Range Including Important Drug Interactions

Digoxin

• Relationship Between Serum Concentration and Response
• Pharmacokinetic Profile (ADME)
• Population Data
• Equation Resource
• Reasons for Request
• Factors Altering Therapeutic Range
• Analytical Methodology

Theophylline

• Therapeutic Range and Evidence-Base
• Pharmacokinetic Profile (ADME)
• Population Data
• Equation Resource
• Reasons for Request
• Factors Affecting Drug Levels, Including Important Drug Interactions

Lithium

• Therapeutic Range
• Therapeutic Range and Evidence-Base
• Pharmacokinetic Profile (ADME)
• Population Data
• Equation Resource and Examples
• Reason for Request
• Factors Affecting Therapeutic Range Including Important Drug Interactions

Antiepileptics

• Epilepsy and Seizures
• Rationale for Therapeutic Drug Monitoring
• Treatment
• Profiles of Antiepileptic Drugs
• Antiepileptic Drugs That Have Little Evidence to Support TDM
• Newer Antiepileptic Drugs

Ciclosporin

• How Ciclosporin Works
• Monitoring of Ciclosporin in Transplant Patients
• Ciclosporin Absorption Profiling
• Accuracy of C₂ Blood Sampling

Clinical Case Studies

Index

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