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Pharmaceutical book from C.H.I.P.S.

Clinical Pharmacokinetics
by Soraya Dhillon

Clinical Pharmacokinetics is a guide to the use of pharmacokinetic principles in routine clinical practice.

Contents

Basic Pharmacokinetics

  • Rates of Reaction
  • Pharmacokinetic Models
  • Pharmacokinetic Parameters
  • Pharmacokinetic Applications

Therapeutic Drug Monitoring

  • TDM - Which Drugs and Why?
  • Education and Training
  • Interpretation of Serum Drug Levels
  • Free Drug Concentration Monitoring
  • Use of Calculators and Computer Software Packages

Clinical Pharmacokinetics in Renal Impairment

  • Assessment of Renal Function
  • Altered Pharamcokinetics
  • Absorption and Bioavailability
  • Distribution
  • Metabolism
  • Excretion
  • Approaches to Drug Dose Alteration in Renal Impairment
  • Maintenance Dose
  • Loading Dose
  • Dialysis
  • Loading Doses of Drugs
  • Administration of Maintenance Doses in Renal Replacement Therapy

The Effect of Liver Dysfunction on Pharmacokinetics

  • Pharmacokinetic Parameters
  • Model Drugs Used as Indicators of Changed Drug Clearance

Clinical Pharmacokinetics in the Elderly

  • Absorption
  • Distribution
  • Metabolism
  • Elimination
  • Other Factors

Aminoglycosides

  • Therapeutic Range and Evidence-Base
  • Pharmacokinetic Profile (ADME)
  • Population Data
  • Equation Resource - Which Equations to Use and When
  • Reasons for Request
  • Factors Affecting Therapeutic Range Including Important Drug Interactions

Digoxin

  • Relationship Between Serum Concentration and Response
  • Pharmacokinetic Profile (ADME)
  • Population Data
  • Equation Resource
  • Reasons for Request
  • Factors Altering Therapeutic Range
  • Analytical Methodology

Theophylline

  • Therapeutic Range and Evidence-Base
  • Pharmacokinetic Profile (ADME)
  • Population Data
  • Equation Resource
  • Reasons for Request
  • Factors Affecting Drug Levels, Including Important Drug Interactions

Lithium

  • Therapeutic Range
  • Therapeutic Range and Evidence-Base
  • Pharmacokinetic Profile (ADME)
  • Population Data
  • Equation Resource and Examples
  • Reason for Request
  • Factors Affecting Therapeutic Range Including Important Drug Interactions

Antiepileptics

  • Epilepsy and Seizures
  • Rationale for Therapeutic Drug Monitoring
  • Treatment
  • Profiles of Antiepileptic Drugs
  • Antiepileptic Drugs That Have Little Evidence to Support TDM
  • Newer Antiepileptic Drugs

Ciclosporin

  • How Ciclosporin Works
  • Monitoring of Ciclosporin in Transplant Patients
  • Ciclosporin Absorption Profiling
  • Accuracy of C2 Blood Sampling

Clinical Case Studies

Index

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Clinical Pharmacokinetics
by Soraya Dhillon
2006 262 pages $55.00 + shipping
Texas residents please add 6.75% sales tax

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