Contemporary Drug Synthesis examines how leading researchers and manufacturers have integrated chemistry, biology, pharmacokinetics, and a host of other disciplines in the creation and development of leading drugs.

Authored by four of the pharmaceutical industry’s most respected scientists, this timely volume:

• Focuses on the processes that resulted in high-profile drugs including Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, and over a dozen others

• Provides an in-depth introduction to each drug, followed by a detailed account of its synthesis

• Organizes the drugs into fourteen therapeutic areas for clarity and ease of use

Contemporary Drug Synthesis meets the needs of a growing community of researchers in pharmaceutical research and development, and is both a useful guide for practicing pharmaceutical scientists and an excellent text for medicinal and organic chemistry students.

Contents

Trade Names and Their Corresponding USANs
Acronyms and Abbreviations

1. Antithrombotics: Ticlopidine (Ticlid®) and Clopidogrel (Plavix®).
2. Anti-inflammatory Cyclooxygenase-2 Selective Inhibitors: Celecoxib (Celebrex®) and Rofecoxib (Vioxx®).
3. H⁺/K⁺ -ATPase Inhibitors: Esomeprazole (Nexium®).
4. Protein-tyrosine Kinase Inhibitors: Imatnib (Gleevec®) and Gefitinib (Iressa®).
5. Non-sedating Antihistamines.
6. Cosmeceuticals: Istretinoin (Accutane®), Tazarotene (Tazorac®), Minoxidil (Rogaine®), and Finasteride (Propecia®).
7. Antibacterials: Ciprofloxacin (Cipro®) and Linezolid (Zyvox®).
8. Atypical Antupsychotics.
9. Atovastatin Calcium (Lipitor®).
10. Antidepressants.
11. Anti-obesity: Orlistat (Xenical®).
12. Triptans for Migrane.
13. PDE 5 Inhibitors for Erectile Dysfunction: Sildenafil (Viagra®), Vardenafil (Levitra®), and Tadalafil (Cialis®).
14. Antiasthmatics

Index

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