Chronic Obstructive Pulmonary Disease is the first up-to-date reference source to include the latest national and international guidelines and newer therapeutic agents in COPD treatment.

Chronic Obstructive Pulmonary Disease includes:

• Structure and physiology of the respiratory system
• Clinical considerations and allied conditions
• Therapy
• Current and developing treatments
• Diagnostic tests used in daily practice

Contents

Physiology

1. Structure-Function Relationships: the Pathophysiology of Airflow Obstruction
2. The Physiology of Breathlessness
3. The Physiology of Muscle
4. Exercise Limitations and Cardiopulmonary Exercise Testing in COPD
5. Clinical Assessment of Control of Breathing
6. Physiology and Pathobiology of the Lung Circulation
7. Sleep in Patients with COPD
8. The Physiology of Cough
9. The Physiology of Gas Exchange

COPD and Allied Conditions

10. The Natural History of COPD
11. Cystic Fibrosis
12. Bronchiectasis and COPD
13. Obliterative Bronchiolitis
14. Asthma
15. COPD: Clinical Presentation and Evaluation
16. Monitoring and Outcomes

Host Defences and Inflammation

17. Mucociliary Clearance
18. Mucosal Immunity
19. COPD and Pulmonary Surfactant
20. The Macrophage and its Role in the Pathogenesis of COPD
21. Eosinophils and COPD
22. Airway Epithelial Defence, Repair and Regeneration
23. The Role of the Neutrophil in the Pathogenesis
24. Lymphocytes
25. Cytokines
26. Leukotrienes in COPD: The Unexploited Potential
27. Cigarette Smoking, Emphysema and Lung Endothelium
28. Mesenchymal Cells of the Lung

Pathogenesis

29. Lung Development
30. Animal Models
31. Proteinases and COPD
32. Oxidants
33. Cigarette Smoke-Induced Disease
34. COPD and Air Pollution
35. Viruses in COPD
36. Bacteria
37. Genetic Factors
38. Antitrypsin Deficiency
39. Body Weight and Systemic Effects
40. Lung Connective Tissue

Clinical Considerations and Complications

41. Aerosols and Delivery Systems
42. Gastro-oesophageal Reflux
43. Upper Airway Diseases
44. Acute Pulmonary Embolism
45. COPD and Lung Cancer
46. Infection Management and Airflow Obstruction
47. Mechanical Ventilation for Exarcerbation of COPD
48. Comorbidity

Current and Future Treatment

49. Primary Care
50. Pulmonary Rehabilitation
51. Social Support
52. Long-Term Invasive Mechanical Ventilation
53. Smoking Cessation
54. Oxygen Therapy in COPD
55. Surgical Therapy for COPD
56. Anticholinergics in COPD
57. Agonists
58. Corticosteroids
59. Phosphodieterase 4 Inhibitors in the Treatment of COPD
60. Antibiotic Therapy in Patients with COPD
61. Antioxidants
62. Mucolytics for COPD
63. End-of-Life and Palliative Care for Patients with COPD
64. Economic Burden of COPD
65. Pharmacoepidemiology of COPD
66. Social and Behavioral Impact of COPD-Research Opportunites

Pharmacotherapy: Developing Therapies

68. Protease Inhibitors
69. Retinoids
70. Chemokines in COPD

Index

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