Coupled Bioluminescent Assays highlights the applications of coupled bioluminescence assay techniques to real-world problems in drug discovery, environmental and chemical analysis, and biodefense. It separates theoretical aspects from the applied sections in a clear and readable way.

The book explains the uses of CB technologies across drug discovery to analyze toxicity, drug receptors, and enzymes. It covers applications in environmental analysis and biodefense, including cytotoxicity, fertilizer and explosives analysis, and nerve agent and pesticide detection. This is the premier reference on coupled bioluminescent assays for chemists, biochemists, and molecular biologists.

Contents

Part I: background to Coupled Bioluminescent Assays

1. Introduction
2. Coupled Bioluminescent Reactions in Practice

Part II: Biomedicat Applications of Coupled Bioluminescence

3. Coupled Bioluminescent Cytotoxicity Assays
4. The Role of Coupled Bioluminescent Assays in Kinase Screening and Study
5. Coupled Bioluminescent Phosphatase Assays.
6. Acetylcholinesterase
7. Measurement of Nitric Oxide Synthase Activity by Coupled Bioluminescence
8. The Coupled Bioluminescent Pyrophosphorolysis Assay
9. Coupled Luminescent Assays of G-Protein-Coupled Receptors
10. Coupled Bioluminescent Protease Assays
11. Coupled Luminescent Assays Involving Aequorin
12. Coupled Bioluminescent Reporter Assays
13. Coupled Bioluminescent Assays: Regulatory Concerns

Part III: Other Applications of Coupled Bioluminescence

14. Coupled Bioluminescent Determination of Bioburden and Sterility
15. Environmental Applications of Coupled Bioluminescent Assays

Appendix: One-Letter Amino Acid Abbreviations
Index

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