Sixth Edition
edited by
Hongbo Zhai
and Howard I. Maibachi
Dermatoxicology includes fundamental information on the mechanisms of action of toxic substances on the skin, as well as practical information on the various methods to evaluating dermal toxicity.
This completely revised and reworked edition constitutes a major contribution to the field of dermatotoxicology.
Presenting the most modern concepts and methods in use today, researchers and clinicians will find this an invaluable resource time and time again.
Features:
- Reflects recent advances in skin toxicology
- Contains 25 new chapters covering concepts and methods
- Describes the current state of knowledge of dermatotoxicology
- Covers the mechanisms of action of toxicants on the skin
Contents:
- Skin Permeability
- Occlusion and Barrier Function
- Percutaneous Absorption of Complex Chemical Mixtures
- Anatomical Factors Affecting Barrier Function
- Percutaneous Absorption: Role of Lipids
- Percutaneous Absorption: Short-Term Exposure, Lag Time, Multiple Exposures, Model Variations, and Absorption from Clothing
- Chemical Partitioning into Powdered Human Stratum Corneum: A Useful In Vitro Model for Studying Interaction of Chemical and Human Skin
- Sensitive Skin
- Transdermal Drug Delivery System - An Overview
- Iontophoresis
- Irritant Dermatitis (Irritation)
- Allergic Contact Dermatitis
- Irritant Contact Dermatitis versus Allergic Contact Dermatitis
- Molecular Basis of Allergic Contact Dermatitis
- Systemic Contact Dermatitis
- Permeability of Human Skin to Metals and Paths for Their Diffusion
- Photoirritation (Phototoxicity, Phototoxic Dermatitis)
- Chemically Induced Scleroderma
- Chemical Agents that Cause Depigmentation
- Sulfur Mustard: A Chemical Vesicant Model
- Carcinogenesis: Current Trends in Skin Cancer Research
- Retinoids and Their Mechanisms to Toxicity
- Skin Disorders Caused by Cosmetics in China
- Drug Induced Ocular Phototoxicity
- Water: Is It an Irritant?
- Sodium Lauryl Sulfate in Dermatotoxicology
- Barrier Creams
- Methods for In Vitro Percutaneous Absorption
- Tape Stripping Method and Stratum Corneum
- Percutaneous Absorption of Hazardous Substances from Soil and Water
- Isolated Perfused Porcine Skin Flap
- Physiologically Based Pharmacokinetic Modeling
- Methods for In Vitro Skin Metabolism Studies
- Transdermal Drug Delivery Systems: Dermatologic and Other Adverse Reactions
- Predictive Toxicology Methods for Transdermal Delivery Systems
- Animal, Human, and In Vitro Test Methods for Predicting Skin Irritation
- Analysis of Structural Change in Intercellular Lipids of Human Stratum Corneum Induced by Surfactants: Electron Paramagnetic Resonance (EPR) Study
- Test Methods for Allergic Contact Dermatitis in Animals
- Test Methods for Allergic Contact Dermatitis in Humans
- Immunoadjuvants in Prospective Testing for Contact Allergens
- The Local Lymph Node Assay
- Contact Urticaria and the Contact Urticaria Syndrome (Immediate Contact Reactions)
- An Optimized In Vitro Approach to Assess Skin Irritation and Phototoxicity of Topical Vehicles
- Photoirritation (Phototoxicity) Testing in Humans
- Measuring and Quantifying Ultraviolet Radiation Exposure
- Use of Pig Skin Preparations in Novel Diffusion Cell Arrays to Measure Skin Absorption and to Evaluate Potential Chemical Toxicity
- Determination of Subclinical Changes of Barrier Function
- Assessing the Validity of Alternative Methods for Toxicity Testing
- Animal Models for Immunologic and Nonimmunologic Contact Urticaria
- Diagnostic Tests in Dermatology: Patch and Photopatch Testing and Contact Urticaria
- Cosmetic Reactions
- Evaluating Efficacy of Barrier Creams: In Vitro and In Vivo Models
- Light-Induced Dermal Toxicity: Effects on the Cellular and Molecular Levels
Index