Dioxins are the most potent, well-known, and long lasting of the persistent organic pollutants (POPS), and are of great interest in public health, toxicology, chemistry, medicine, law, and to regulatory agencies worldwide.

In the years since publication of the first edition of Dioxins and Health, major advances have been made in human epidemiology as well as in animal studies. This second edition updates the science involved in the dioxin and PCB literature.

Contents

1. Overview: The Dioxin Debate
2. Production, Distribution and Fate of Polychlorinated Dibenzo-p-dioxins, Dibenzofurans, and Related Organohalogens in the Environment
3. Dioxins in Food
4. Toxicology of Dioxins and Dioxin-like Compounds
5. Health Risk Characterization of Dioxin and Related Compounds
6. Pharmacokinetics of Dioxins and Related Chemicals
7. Dose Response Modeling for 2,3,7,8-Tetrachlorodibenzo-p-dioxin
8. Immunotoxicology of Dioxins and Related Chemicals
9. Developmental and Reproductive Toxicity of Dioxins and Related Chemicals
10. Effects of Polychlorinated Biphenyls on Neuronal Signaling
11. Experimental Toxicology: Carcinogenesis
12. The Ah Receptor: Involvement in Toxic Responses
13. Biochemical Responses to Dioxin: Which Genes? Which Endpoints?
14. Evolutionary and Physiological Perspectives on Ah Receptor Function and Dioxin Toxicity
15. Dioxin Toxicity and Aryl Hydrocarbon Receptor Signaling in Fish
16. Exposure Assessment: Measurement of Dioxins and Related Chemicals in Human Tissues
17. Human Health Effects of Polychlorinated Biphenyls
18. Epidemiological studies on cancer and exposure to dioxins and related compounds
19. Reproductive and Developmental Epidemiology of Dioxins
20. Health Consequences of the Seveso, Italy, Accident
21. The Yusho Rice Oil Poisoning Incident
22. The Yucheng Rice Oil Poisoning Incident

Index

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