The Drug Discovery Handbook gives professionals a tool to facilitate drug discovery by bringing together, for the first time in one resource, a compendium of methods and techniques that need to be considered when developing new drugs.

This comprehensive, practical guide presents an explanation of the latest techniques and methods in drug discovery, including:

• Genomics, proteomics, high-throughput screening, and systems biology
• Summaries of how these techniques and methods are used to discover new central nervous system agents, antiviral agents, respiratory drugs, oncology drugs, and more
• Specific approaches to drug discovery, including problems that are encountered, solutions to these problems, and limitations of various methods and techniques

The thorough coverage and practical, scientifically valid problem-solving approach of Drug Discovery Handbook will serve as an invaluable aid in the complex task of developing new drugs.

Contents

1. Natural products
2. Cancer Cell Proteomics Using Molecular Aptamers
3. Molecular Similarity Methods and QSAR Models as Tools for Virtul Screening
4. Systems Biology: Applications in Drug Discovery
5. High-Throughput Flow Cytometry
6. Combining NMR Spectral Information with Associated Structural Features to Form Computationally Nonintensive, Rugged, and Objective Models of Biological Activity
7. Using Microsoft Excel® as a Laboratory Data Management Tool
8. Age of Regulation
9. Simultaneous Screening of Multiple Cell Lines Using the CellCard System
10. Protein X-Ray Crystallography in Drug Discovery
11. Biological and Chemistry Assays Available During Drug Discovery and Developability Assessment
12. Strategies and Methods in Monitoring and Targeting Protein-Protein Interactions
13. High-Throughput Screening: Evolution of Technology and Methods
14. Metal-Enhanced Fluorescence: Application to High-Throughput Screening and Drug Discovery
15. Methods for the Design and Analysis of Replicate-Experiment Studies to Establish Assay Reproducibility and the Equivalence of Two Potency Assays
16. Coupled Luminescent Methods in Drug Discovery: 3-Min Assays for Cytotoxicity and Phosphatase Activity
17. Design and Pharmaceutical Applications of Prodrugs
18. GABA and Glutamate Receptor Ligands and Their Therapeutic Potential in CNS Disorders
19. Cardiac Sarcolemmal ATP-Sensitive Potassium Channel Antagonists: Novel Ischemia-Selective Antiarrhythmic Agents
20. Factors Influencing the Efficacy of Mediator-Specific Anti-inflammatory, Glucocorticoid, and Anticoagulant Therapies for Sepsis
21. Combinatorial Chemistry in the Drug Discovery Process
22. Herbal Medicines and Animal Models of Gastrointestinal Diseases
23. Endocrine and Metabolic Agents
24. Respiratory Viruses
25. Strategie sin the Design of Antiviral Drugs
26. Protein Kinase Inhibitors in Drug Discovery
27. RNA-Based Therapies
28. Novel Imaging: Agents for Molecular MR Imaging of Cancer
29. Targets and Approaches for Cancer Drug Discovery

Index

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ORDER NOW Drug Discovery Handbook by Shayne Cox Gad 2005 • 1,471 pages • $179.00 + shipping Texas residents please add 6.75 % sales tax