Epidemiological studies have found that drugs are now the most common cause of liver failure in the United States, and the past decade has seen an explosion of new information concerning the immunology, toxicology, and pharmacology of drug-induced liver disease.

Drug-Induced Liver Disease supplies an in-depth discussion of the recent developments in drug-induced hepatotoxicity, covering mechanisms, histopathology, management, risk factors, and patterns of drug and toxin-induced liver disease.

Features:

• contains an abundance of new chapters
• updates readers on the diagnosis and management of liver disease and addresses current issues
• provides a systematic review of the major xenobiotics associated with drug-induced liver disease
• includes a new section on regulatory perpectives
• divides chapters into three reader-friendly sections that delve into the mechanisms of hepatotoxicity and specific classes of drugs or toxins used within a clinical specialty

Drug-Induced Liver Disease offers contributions from international authorities seasoned in topics such as pathogenesis, clinical presentation, and drugs and toxins of importance to this field.

Contents

Mechanisms of Liver Injury

1. Drug-Induced Liver Disease
2. Cytochrome P450 Activation of Toxins and Hepatoxicity
3. Antioxidant Defense in Liver Injury: Oxidant Stress, Antioxidant Defense, and Liver Injury
4. Hepatotoxicity Due to Mitochondrial Injury
5. Mechansims of Cell Death and Relevance to Drug Hepatotoxicity
6. Significance of Hepatobiliary Trasnporters for Drug-Induced Liver Disease
7. Immunological Mechansims in Drug-Induced Liver Injury
8. Mechanistic Role of Acyl Glucuronides
9. Nonparenchymal Cells, Inflammatory Macrophages, and Hepatotoxicity
10. Role of Tissue Repair in Liver Injury
11. Genetic Susceptibility to Drug-Induced Liver Disease

Diagnosis and Management

12. Clinicopathological Patterns of Drug-Induced Liver Disease
13. Histopathology of Drug-Induced Liver Disease
14. Risk Factors for Drug-Induced Liver Disease
15. Genomics, Proteomics, and Metabolomics in the Diagnosis and Mechanisms of Drug-Induced Liver Disease
16. Causality Assessment
17. Management of the Patient with Drug-Induced Liver Disease

Hepatotoxicity of Specific Drugs

18. Mechanisms of Acetaminophen-Induced Liver Disease
19. Acetaminophen: Pathology and Clinical Presentation of Hepatotoxicity
20. Mechansims Underlying the Hepatotoxicity of Nonsteriodal Anti-Inflammatory Drugs
21. Nonsteroidal Anti-inflammatory Drugs and Leukotrien Receptor Antagonists: Pathology and Clinical Presentation of Hepatotoxicity
22. Mechanism, Pathology, and Clinical Presentation of Hepatotoxicity of Anesthetic Agents
23. Anticonvulsant Agents
24. Hepatotoxicity of Psychotropic Drugs and Drugs of Abuse
25. Antibacterial and Antifungal Agents
26. Hepatotoxicity of Antituberculosis Drugs
27. Hepatic Toxicity of Antiviral Agents
28. Hepatotoxicity of Cardiovascular and Antidiabetic Medications
29. Cancer Chemotherapy
30. Hepatotoxicity of Immunomodulating Agents and the Transplant Situation
31. Methotrexate Controversies
32. Adverse Effects of Hormones and Hormone Antagonists on the Liver
33. Mushroom Poisoning: A Clinical Model of Toxin-Induced Centrilobular Necrosis
34. Hepatoxicity of Herbal Medicines, Vitamins, and Natural Hepatotoxins
35. Occupational and Environmental Hepatotoxicity

Regulatory Perspectives

36. Regulatory Perspectives

Index

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ORDER NOW Drug-Induced Liver Disease Second Edition edited by Neil Kaplowitz 2007 • 808 pages • $328.95 + shipping Texas residents please add 6.75 % sales tax