Medical book from C.H.I.P.S.

Drug-Induced Liver Disease
Second Edition
edited by Neil Kaplowitz

Epidemiological studies have found that drugs are now the most common cause of liver failure in the United States, and the past decade has seen an explosion of new information concerning the immunology, toxicology, and pharmacology of drug-induced liver disease.

Drug-Induced Liver Disease supplies an in-depth discussion of the recent developments in drug-induced hepatotoxicity, covering mechanisms, histopathology, management, risk factors, and patterns of drug and toxin-induced liver disease.


  • contains an abundance of new chapters
  • updates readers on the diagnosis and management of liver disease and addresses current issues
  • provides a systematic review of the major xenobiotics associated with drug-induced liver disease
  • includes a new section on regulatory perpectives
  • divides chapters into three reader-friendly sections that delve into the mechanisms of hepatotoxicity and specific classes of drugs or toxins used within a clinical specialty

Drug-Induced Liver Disease offers contributions from international authorities seasoned in topics such as pathogenesis, clinical presentation, and drugs and toxins of importance to this field.


Mechanisms of Liver Injury

  1. Drug-Induced Liver Disease
  2. Cytochrome P450 Activation of Toxins and Hepatoxicity
  3. Antioxidant Defense in Liver Injury: Oxidant Stress, Antioxidant Defense, and Liver Injury
  4. Hepatotoxicity Due to Mitochondrial Injury
  5. Mechansims of Cell Death and Relevance to Drug Hepatotoxicity
  6. Significance of Hepatobiliary Trasnporters for Drug-Induced Liver Disease
  7. Immunological Mechansims in Drug-Induced Liver Injury
  8. Mechanistic Role of Acyl Glucuronides
  9. Nonparenchymal Cells, Inflammatory Macrophages, and Hepatotoxicity
  10. Role of Tissue Repair in Liver Injury
  11. Genetic Susceptibility to Drug-Induced Liver Disease

Diagnosis and Management

  1. Clinicopathological Patterns of Drug-Induced Liver Disease
  2. Histopathology of Drug-Induced Liver Disease
  3. Risk Factors for Drug-Induced Liver Disease
  4. Genomics, Proteomics, and Metabolomics in the Diagnosis and Mechanisms of Drug-Induced Liver Disease
  5. Causality Assessment
  6. Management of the Patient with Drug-Induced Liver Disease

Hepatotoxicity of Specific Drugs

  1. Mechanisms of Acetaminophen-Induced Liver Disease
  2. Acetaminophen: Pathology and Clinical Presentation of Hepatotoxicity
  3. Mechansims Underlying the Hepatotoxicity of Nonsteriodal Anti-Inflammatory Drugs
  4. Nonsteroidal Anti-inflammatory Drugs and Leukotrien Receptor Antagonists: Pathology and Clinical Presentation of Hepatotoxicity
  5. Mechanism, Pathology, and Clinical Presentation of Hepatotoxicity of Anesthetic Agents
  6. Anticonvulsant Agents
  7. Hepatotoxicity of Psychotropic Drugs and Drugs of Abuse
  8. Antibacterial and Antifungal Agents
  9. Hepatotoxicity of Antituberculosis Drugs
  10. Hepatic Toxicity of Antiviral Agents
  11. Hepatotoxicity of Cardiovascular and Antidiabetic Medications
  12. Cancer Chemotherapy
  13. Hepatotoxicity of Immunomodulating Agents and the Transplant Situation
  14. Methotrexate Controversies
  15. Adverse Effects of Hormones and Hormone Antagonists on the Liver
  16. Mushroom Poisoning: A Clinical Model of Toxin-Induced Centrilobular Necrosis
  17. Hepatoxicity of Herbal Medicines, Vitamins, and Natural Hepatotoxins
  18. Occupational and Environmental Hepatotoxicity

Regulatory Perspectives

  1. Regulatory Perspectives


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Drug-Induced Liver Disease
Second Edition
edited by Neil Kaplowitz

2007 808 pages $328.95 + shipping
Texas residents please add 6.75 % sales tax

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