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Drug Development Book from C.H.I.P.S.

Drug Discovery Strategies and Methods edited by
Alexandros Makriyannis
and Diane Biegel

Navigate the complex, multidisciplinary path of drug discovery procedures with Drug Discovery Strategies and Methods—a well-organized and timely reference analyzing current methods in target identification and validation, lead detection, compound optimization, and biological testing.

Drug Discovery Strategies and Methods considers key elements in the drug design cycle ranging from

  • appropriateness of targets and disease models
  • compound characterization, safety, and efficacy
  • the role of protein crystallography in structure-based drug design
  • the use of PET or SPECT in the determination of antagonist drug efficacy and evaluation of CB1 receptor transformation in addiction and other diseases
  • advances in the development of peptide-derived pharmaceuticals
  • the molecular features of protein misfolding in neurodegenerative diseases
  • new techniques in antirhinovirus drug design
  • to the anti-HIV activity of a variety of compounds

It addresses challenges encountered during the discovery of new pharmaceutical candidates including the use of cutting-edge techniques utilized in drug design and development.

Contents

  1. Protein Crystallography in Structure-Based Drug Desing
  2. Src Homology-2 Domains and Structure-Based, Small-Molecule Library Approaches to Drug Discovery
  3. Three-Dimensional Structure of the Inhibited Catalytic Domain of Human Stromelysin-1 by Heteronuclear NMR Spectroscopy
  4. Cannabinergics: Old and New Possibilities
  5. Development of PET and SPECT Radioligands for Cannabinoid Receptors
  6. Structural and Pharmacological Aspects of Peptidomimetrics
  7. Linkers and Resins for Solid-Phase Synthesis: 1997-1999
  8. Allosteric Modulation of G-Protein-Coupled Receptors: Implications for Drug Action
  9. Protein Misfolding and Neurodegenerative Disease: Therapeutic Opportunities
  10. Uncoating and Adsorption Inhibitors of Rhinovirus Replication
  11. Profiles of Prototype Antiviral Agents Interfering with the Initial Stages of HIV Infection

Index

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Drug Discovery Strategies and Methods
edited by Alexandros Makriyannis and Diane Biegel
2004 348 pages $189.95 + shipping

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