Drug-Induced Mitochondrial Dysfunction discusses mitochondrial impairment to organs, skeletal muscle, and nervous systems and details methodologies used to assess mitochondria function.

Drug-Induced Mitochondrial Dysfunction explains concepts so that non-specialists can understand mitochondrial function.

Drug-Induced Mitochondrial Dysfunction covers both in vitro and in vivo methods for analysis and includes the latest models.

Contents

Basic Concepts

1. Basic Mitochondrial Physiology in Cell Viability and Death
2. Basic Molecular Biology of Mitochondrial Replication
3. Drug-Associated Mitochondrial Toxicity
4. Pharmacogenetics of Mitochondrial Drug Toxicity

Organ Drug Toxicity: Mitochondrial Etiology

5. Features and Mechanisms of Drug-Induced Liver Injury
6. Cardiovascular Toxicity of Mitochondrial Origin
7. Skeletal Muscle and Mitochondrial Toxicity
8. Manifestations of Drug Toxicity on Mitochondria in the Nervous System
9. Lipoatrophy and Other Manifestations of Antiretroviral Therapeutics
10. Nephrotoxicity
11. Drug Effects in Patients with Mitochondrial Diseases

Assessment of Mitochondrial Function in Vitro and in Vivo

12. Polarographic Oxygen Sensors, the Oxygraph, and High-Resolution Respirometry to Assess Mitochondrial Function
13. Use of Oxygen-Sensitive Fluorescent Probes for the Assessment of Mitochondrial Function
14. Mitochondrial Dysfunction Assessed Quantitatively in Real Time by Measuring the Extracellular Flux of Oxygen and Protons
15. Assessment of Mitochondrial Respiratory Complex Function in Vitro and in Vivo
16. OXPHOS Complex Activity Assays and Dipstick Immunoassays for Assessment of OXPHOS Protein Levels
17. Use of Fluoresvent Reporters to Measure Mitochondrial Membrane Potential and the Mitochondrial Permeability Transition
18. Compartmentation of Redox Signaling and Control: Discrimination of Oxidative Stress in Mitochondria, Cytoplasm, Nuclei, and Endoplasmic Reticulum
19. Assessing Mitochondrial Protein Syntesis in Drug Toxicity Screening
20. Mitochondrial Toxicity of Antiviral Drugs: A Challenge to Accurate Diagnosis
21. Clinical Assessment of Mitochondrial Function via [¹³C]Methionine Exhalation
22. Assessment of Mitochondrial Dysfunction by Microscopy
23. Development of Animal Models of Drug-Induced Mitochondrial Toxicity
24. Noninvasive Assessment of mitochondrial Function Using Nuclear Magnetic Resonance Spectroscopy
25. Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations

Index

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