Drug Transporters is a comprehensive guide to drug transporters that influence the absorption, distribution, and elimination of drugs in the body.

Features of Drug Transporters: Molecular Characterization and Role in Drug Disposition:

• Provides a comprehensive overview of drug transporters
• Includes specific descriptions of transporter families, including substrate and inhibitor specificity, subcellular and tissue localization, mechanisms governing transport, species differences, the clinical implications of these transporters in human physiology and disease, and their role in drug distribution, elimination, and interactions in drug therapy
• Describes transporter-mediated drug disposition, a newly emerging field in drug therapy
• Gives a comprehensive summary of drug transport across biological membranes in the liver, brain, kidney, and intestine
• Provides balanced coverage of mechanistic aspects and functional outcomes
• Features chapters contributed by distinguished scientists in their specialty areas
• Provides sufficient detail to enable non-specialists to understand the principles and techniques

Contents

1. Overview of Drug Transporter Families
2. Organic Cation Transporters
3. Organic Cation/Carnitine Transporters
4. Organic Anion Transporters
5. Organic Anion–Transporting Polypeptides
6. Mammalian Oligopeptide Transporters
7. Monocarboxylate Transporters
8. Nucleoside Transporters: CNTs and ENTs
9. Bile Acid Transporters
10. Multidrug Resistance Protein: P-Glycoprotein
11. Multidrug Resistance Proteins of the ABCC Subfamily
12. Breast Cancer Resistance Protein
13. Drug Transport in the Liver
14. Drug Transport in the Brain
15. Drug Transport in the Kidney
16. Drug Transporters in the Intestine
17. Regulation of Drug Transporter Activity
18. Experimental Approaches to the Study of Drug Transporters
19. In Vitro–In Vivo Scale-up of Drug Transport Activities
20. Age- and Gender-Related Differences in Xenobiotic Transporter Expression
21. Polymorphisms of Drug Transporters and Clinical Relevance
22. Diet/Nutrient Interactions with Drug Transporters
23. Interplay of Drug Transporters and Enzymes on Hepatic Drug Processing
24. Clinical Relevance: Drug–Drug Interactions, Pharmacokinetics, Pharmacodynamics, and Toxicity

Index

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