Enzyme Systems that Metabolise Drugs and Other Xenobiotics describes in detail the enzyme systems that participate in the metabolism of xenobiotics, particularly medicinal drugs. Each chapter focuses on a specific enzyme system, emphasising its role in the activation and detoxication of chemicals.

Aspects discussed critically include:

• enzyme function in the metabolism and bioactivation of xenobiotics
• substrate specificity
• tissue distribution
• species distribution (to include laboratory animals and humans)
• hormonal regulation
• sex differences
• modulation by prior exposure to other chemicals
• age-dependent expression
• pharmacogenetics and modulation by disease

Enzyme Systems that Metabolise Drugs and Other Xenobiotics will be essential reading for industrial research scientists working in the fine chemicals and pharmaceutical industries, especially those concerned with the safety evaluation of chemicals, and investigating their metabolism, pharmacokinetic characteristics and toxicological properties.

Contents

1. Xenobiotic Metabolism: An Overview
2. Cytochrome P450
3. Flavin Monooxygenases
4. Amine Oxidases and the Metabolism of Xenobiotics
5. Molybdenum Hydroxylases
6. Prostaglandin Synthases
7. Lipoxygenases
8. UDP-Glucuronosyltranferases
9. Glutathione S-transferases
10. Sulphotransferases
11. Arylamine Acetyltransferases
12. Mammalian Xenobiotic Epoxide Hydrolases
13. Methyltransferases
14. The Amino Acid Conjugations
15. Deconjugating Enzymes; Sulphatases and Glucuronidases
16. Nitroreductases and Azoreductases

Index

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