Enzyme Technologies: Metagenomics, Evolution, Biocatalysis, and Biosynthesis provides in-depth reviews of recent developments in selective topics on biosynthesis, biocatalysis, and chemical biology of enzymes as it applies to drug discovery, development, and manufacture.

This volume features three sections:

1. New Approaches to Finding and Modify Enzymes describes the emerging field of metagenomics, presents the practical applications of directed evolution to enzymes and pathways, and explores approaches for the discovery and design of biocatalysts
2. Biocatalytic Applications reviews specific applications of different reactions in producing active pharmaceutical ingredients and surveys recent developments employing enzymes in organic synthesis
3. Biosynthetic Applications goes over successful drug discoveries and developments by combinatorial biosynthesis and reviews the application of combinatorial biosynthesis among multiple compatible hosts

Theis timely book covers everything from chemical biology of enzymes, to the redesign of binding and catalytic specificities of enzymes.

Contents

New Approaches to Finding and Modifying Enzymes

1. Functional Metagenomics as a Technique for the Discovery of Novel Enzymes and Natural Products
2. Directed Enzyme and Pathway Evolution
3. Combining Natural Biodiversity and Molecular-Directed Evolution to Develop New Industrial Biocatalysts and Drugs
4. Principles of Enzyme Optimization for the Rapid Creation of Industrial Biocatalysts

Biocatalytic Applications

5. Enzyme Catalyiss in the Synthesis of Active Pharmaceutical Ingredients
6. Enzymatic Processes for the Production of Pharmaceutical Intermediates
7. Novel Developments Employing Redox Enzymes: Old Enzymes in New Clothes

Biosynthetic Applications

8. Drug Discovery and Development by Combinatorial Biosynthesis
9. Reprogramming Daptomycin and A54145 Biosynthesis to Produce Novel Lipopeptide Antibiotics
10. Pathway and Enzyme Engineering and Applications for Glycodiversification

Index

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