Epigenetic Targets in Drug Discovery surveys current methodologies for finding and validating drug candidates that act via epigenetic mechanisms.
Epigenetic Targets in Drug Discovery covers everything a drug researcher needs to know about targeting epigenetic mechanisms of disease.
Contents
General aspects and methodologies
- New Frontiers in Epigenetic Modifications
- Structural Biology of Epigenetic Targets
- Computer- and Structure-based Lead Identification for Epigenetic Targets
- Histone Modification Analysis Using Mass Spectrometry
- In-vitro Assays for Histone Modifying Enzymes
- Epigenetic Targets in Drug Discovery: Cell-based assays for HDAC inhibitor hit validation
- Chromatin Immuno Precipitation ChIP: wet lab meets in silico
Epigenetic Target Classes and Inhibitor Development
- DNA Methyltransferase Inhibitors
- Histone Deacetylase Inhibitors
- NAD-Dependent Deacetylases as Therapeutic Targets
- Inhibitors of Histone Acetyltransferases: Discovery and Biomedical Perspectives
- Histone Methyltransferases as Novel Drug Targets.
- Histone Demethylases
Index
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