Medical book from C.H.I.P.S.

Epilepsy Surgery
Second Edition
by Hans O. Lüders

Epilepsy Surgery provides detailed information on the vital role of structural and functional neuroimaging in presurgical evaluation and surgical planning.


History of Pioneers of Surgery of Epilepsy

  • History of Epilepsy Surgery: Introduction
  • Contributions of Fedor Krause and Otfrid Foerster to Epilepsy Surgery
  • Contributions of Jean Talairach and Jean Bancaud
  • Contributions of Hugo Krayenbühl and M. Gazi Yasargil to Epilepsy Surgery


  • Epidemiology of Intractable Epilepsy
  • General Concepts of Medical Intractability
  • Ethical Considerations: Informed Consent
  • Cost, Accessibility, and Quality-of-Life Issues in Surgery of Epilepsy

Epileptic Syndromes Remediable by Epilepsy Surgery

  • A New Approach for Classification of Epileptic Syndromes and Epileptic Seizures
  • Mesial Temporal Lobe Sclerosis
  • Neocortical Temporal Lope Epilepsy
  • Lateral Frontal Lope Epilepsies
  • Mesial Frontal Lobe Epilepsy
  • Surgically Remediable Syndromes: Parieto-Occipital Epilepsy
  • Surgical Treatment of Epilepsy in Infants
  • Rasmussen's Syndrome
  • The Hemispheric Epileptic Disorders: Indications for Hemispherectomy
  • Lennox-Gastaut Syndrome: A Surgically Remediable Epilepsy?

Presurgical Evaluation

  • Preoperative Evaluation in Epilepsy Surgery: Some Principal Considerations
  • General Principles of Presurgical Evaluation

Structural Neuroimaging

  • Introduction to Structural Neuroimaging
  • Neuroimaging of Brain Cortex Using Magnetic Resonance
  • Neuroimaging of the Temporal Lobe
  • Structural Neuroimaging in the Presurgical Evaluation of Patients with Malformations of Cortical Development and Neurocutaneous Syndromes
  • Neoplastic Disorders, Vascular Abnormalities, and Other Disorders Causing Epilepsy

Functional Neuroimaging

  • Positron Emission Tomography in Epilepsy Surgery Evaluation
  • Evaluation of Epilepsies Using Proton Magnetic Resonance Spectroscopy
  • Ictal Functional Magnetic Resonance Imaging
  • Cortical Mapping Using Transcranial Electromagnetic Stimulation
  • Multimodality Imaging
  • Future of Neuroimaging in Epilepsy Surgery

Design of an Intensive Epilepsy Monitoring Unit

  • Architectural and System Planning
  • Electroencephalographic Technology
  • Nursing Care
  • Computer Systems: Function and Integration
  • Automatic Detection of Epileptic Seizures
  • Digital Tools for Reviewing the Electroencephalogram: Montage Reformatting, Filtering, and Principal Component Analysis
  • Source Localization and Imaging Techniques
  • Tracking Clinical and Research Information

Noninvasive Electroencephalographic and Magnetoencephalographic Evaluation

  • Interictal Electroencephalography in Temporal Lobe Epilepsy
  • Interictal Electroencephalography in Neocortical Epilepsy
  • Long-Term Noninvasive Videoelectroencephalographic Monitoring in Temporal Lobe Epilepsy
  • Ictal Electroencephalography in Necortical Epilepsy
  • Magnetoencephalography: Its Clinical Usefulness in Epilepsy Surgery
  • Effect of Anticonvulsant Withdrawl on Seizure Semiology
  • Effect of Anticonvulsant Withdrawl on Interictal and Ictal Electroencephalography
  • Limitations of Noninvasive Electroencephalographic Evaluation

Neuropsychology and Psychiatry

  • Presurgical Psychiatric Workup
  • Overview: Presurgical Neuropsychological Evaluation
  • Neuropsychological Correlates of Neuroimaging in Epilepsy Surgery
  • Presurgical Neuropsychological Evaluation for Localization and Lateralization of the Epileptogenic Zone
  • Risk Factors Associated with Postsurgical Decrements in Memory
  • Neuropsychological Examination of Children and Mentally Retarded Adults with Epilepsy
  • Event-Related Potentials in Temporal Lobe Epilepsy
  • Neuropsychological Evaluation in Epilepsy Surgery

Sodium Amobarbital Test

  • Intracorotid Amobarbital Test to Define Language Lateralization
  • Wada Testing to Define Hippocampal Function
  • Use of the Intracarotid Amobarbital Procedure in the Lateralization of the Epileptogenic Zone
  • Reliability of the Intracarotid Amobarbital Procedure

The Management Meeting

  • The Patient Management Conference

Invasive Electroencephalography

  • Indications for Invasive Videoelectroencephalographic Monitoring
  • Indications for Invasive Videoelectroencephalographic Evaluation: Special Considerations in Children
  • Foramen Ovale Electrodes
  • Epidural Electrodes
  • Subdural Electrodes
  • Depth Electrodes
  • Combined Use of Subdural and Depth Electrodes

Surgical Therapeutic Procedures

  • Anesthesia for Epilepsy Surgery
  • Cortical Mapping
  • Electrocorticography
  • Surgery for Mesial Temporal Sclerosis
  • Surgery for Lesional Temporal Lobe Epilepsy
  • Surgery for Neocortical Temporal Lobe Epilepsy
  • How to Select the Best Surgical Procedure for Patients with Temporal Lobe Epilepsy
  • Surgical Treatment for Frontal Lobe Epilepsy
  • The Transsylvian Functional Hemispherectomy: Patient Selection and Results
  • Surgery for Parieto-Occipital Epilepsy
  • Surgery for Neocortical Epilepsy
  • Functional Hemispherectomy: Evolution of Technique and Results in 65 Cases
  • From Hemispherectomy to Hemispherotomy
  • Corpus Callosotomy
  • Surgery for Epilepsy in Childhood
  • How to Select the Best Surgical Procedure for Children with Epilepsy
  • Epilepsy Surgery for Focal Malformations of Cortical Development
  • Epilepsy Surgery for Tumors, Vascular Malformations, Trauma, and Cerebrovascular Disease
  • Multiple Subpial Transection Versus Callosal Section in the Treatment of Experimentally Induced Cortical Focal Seizures
  • Multiple Subpial Transections
  • Vagus Nerve Stimulation in Epilepsy
  • High-Frequency Stimulation of the Subthalamic Nucleus in Epilepsy
  • Role of Low-Level Direct Current in Quenching Amygdala-Kindled Seizure Development and Expression

Surgical Outcome

  • Psychiatric Outcome
  • Psychosocial Outcome Following Epilepsy Surgery: A Review of Controlled Studies
  • Neuropsychological and Psychosocial Outcome in Children
  • Subjective Evaluation of Postsurgical Neuropsychological Deficits
  • Neurological Deficits After Resections of Neocortical Eloquent Areas
  • Complications of Hemispherectomy

Postsurgical Management

  • Postsrugical Pharmacotherapy: Discontinuation of Anticonvulsants
  • Postsurgical Rehabilitation

Neuropathology and Research on Surgical Specimens

  • Pathology of Cortical Dysplasia and Malformed Brain in Neurocutaneous Syndromes
  • Pathology of Neoplastic Lesions Causing Epilepsy
  • In vitro Electrophysiological Studies on the Mechanisms of Epileptogenesis Using Human and Animal Brain Slices
  • Research on Neurotransmitters in Human Epileptic Hippocampus

Surgical Failures - Reoperataion

  • Surgical Failures - Reoperation

Controversies in Epilepsy Surgery

  • What Tests are Needed to Define the Epileptogenic Zone in Patients with Malformation of Cortical Development?
  • Is Surgical Treatment Indicated in Patients with Bitemporal Lobe Epilepsy?
  • Lesionectomy as a Treatment for Chronic Epilepsy: Is it Sufficient for a Good Outcome?


  • Protocols and Outcome Statistics from Epilepsy Surgery Centers
  • Essentials for the Establishment of an Epilepsy Surgery Program
  • Proposal for a New Classification of Outcome with Respect to Epileptic Seizures Following Epilepsy Surgery
  • Classification of Surgical Outcome with Respect to Quality of Life
  • Technological Requirements for Long-Term Monitoring
  • Epilepsy Surgery in Patients with Nonlesional Focal Epilepsy
  • Indications and Timing of Surgery of Catastrophic Epilepsy


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Epilepsy Surgery
Second Edition
by Hans O. Lüders

2001 1,060 pages $198.00 + shipping
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