Extrapolation Practice for Ecotoxicological Effect Characterization of Chemicals identifies data needs and situations where these extrapolations can be most usefully applied, making it a practical guide to the application of extrapolation procedures.

Extrapolation Practice for Ecotoxicological Effect Characterization of Chemicals:

• Includes in-depth coverage of environmental risk assessment and uncertainty
• Discusses biochemical and physiological responses ranging from individual organs and tissues to the complex interactions that occur within entire ecosystems and landscapes
• Reviews readily available (Q)SAR approaches, species-to-species extrapolation, and the use of these in regulatory situations
• Covers the extrapolation of effects across levels of biological organization
• Presents extrapolation tools for mixtures of defined and undefined components and how to use them
• Addresses the differences between organisms in diverse biogeographic regions and extrapolation from smaller to larger spatial units

Extrapolation Practice for Ecotoxicological Effect Characterization of Chemicals on the extrapolation of chemical effects and covers the extrapolation of exposures in the context of interactions between toxicants and the matrix.

Contents

1. Extrapolation in the Context of Criteria Setting and Risk Assessment
2. Matrix and Media Extrapolation
3. (Q)SAR and Extrapolation
4. Extrapolation of Effects Measures Across Levels of Biological Organization in Ecological Risk Assessment
5. Mixture Extrapolation Approaches
6. Temporal Extrapolation in Ecological Effect Assessment of Chemicals
7. Spatial Extrapolation in Ecological Effect Assessment of Chemicals
8. Guidance on the Application of Extrapolation Methods in Ecological Exposure and Effects
9. Characterization of Chemicals

Index

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