Fatty Acids and Lipotoxicity in Obesity and Diabetes deals with the molecular aspects of fatty acid action in obesity and insulin resistance.

Fatty Acids and Lipotoxicity in Obesity and Diabetes includes:

• lipid metabolism
• adipose tissue biology
• ß cell function
• insulin resistance

Contents

1. Transcriptional control of energy homeostasis through the PGC1 coactivators
2. Human obesity and insulin resistance: lessons from experiments of nature
3. Lipid-induced metabolic dysfunction in skeletal muscle
4. Stearoyl-CoA desaturase deficiency, hypercholesterolaemia, cholestasis and diabetes
5. The role of lipin 1 in adipogenesis and lipid metabolism
6. The role of the AMP-activated protein kinase in the regulation of energy homeostasis
7. Endoplasmic reticulum stress and inflammation in obesity and type 2 diabetes
8. The impact of insulin resistance on macrophage death pathways in advanced atherosclerosis
9. Fatty acid transport in adipocytes and the development of insulin resistance
10. Vectorial acylation: linking fatty acid transport and activation to metabolic trafficking
11. Lipid storage and mobilization pathways in yeast
12. Cide proteins and the development of obesity
13. Visualizing brown adipose tissue with FDG-PET
14. Adiponectin and adiponectin receptors in obesity-linked insulin resistance
15. Anti-inflammatory and antidiabetic roles of PPAR?
16. Nutrition, ageing and lipotoxicity

Index

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