Part 1: The health benefits of functional dairy products

Chapter 2: Cancer

• The relationship between diet and cancer
• Colon carcinogenesis
• Colorectal cancer and dairy products
• Calcium
• Casein
• Whey
• Conjugated linoleic acid
• Sphingolipids
• Prebiotics and probiotics
• Mechanisms of anticarcinogenicity and antigenotoxicity for probiotics and prebiotics

• Risk factors in coronary heart disease
• Lipoprotein metabolism and coronary heart disease
• Diet and coronary heart disease
• The effects of probiotics on coronary heart disease
• The effects of prebiotics on coronary heart disease
• The effects of synbiotics on coronary heart disease

• The epidemiology of osteoporosis
• Dairy products, calcium intake and calcium absorption
• Dairy products and osteoporosis
• Genetic markers of osteoporosis risk
• Redefining a nutritional prescription for optimal bone health

• The mechanisms and symptoms of food allergy
• The prevalence of food allergy
• Probiotics and food allergy: the clinical evidence
• Mechanisms of action: gut microbiota composition and food allergy
• Infant development and allergic sensitisation
• Selecting the right probiotic

• The immune system
• Immunosenescence
• Nutrition and immune function in the elderly
• Bovine milk and immunomodulation
• Milk proteins
• Antibodies and other protective agents in milk
• Fermented dairy products and probiotic lactic acid bacteria (LAB)
• Immunomodulatory effects of fermented milk products and LAB

Chapter 7: The therapeutic use of probiotics in gastrointestinal inflammation

• Bacteria in the gut
• Studying gut flora
• Gut flora and intestinal function
• Gut immune function
• Microbial subversion of intestinal immunosensory function
• Bacterial translocation
• Intestinal bacteria and inflammatory bowel disease (IBD)
• Modifying the gut flora: probiotics in practice

Chapter 8: Caseinophosphopeptides (CPPs) as functional ingredients

• Structural characteristics and production of CPPs
• CPPs and mineral (calcium) bioavailability
• Human studies with CPPs
• Effects of CPPs on mineral uptake in specific cell systems
• Cytomodulatory effects
• Safety assessment of CPPs
• Potential ingredient application of CPPs

• Structural aspects of free oligosaccharides
• Physiological functions of dietary oligosaccharides
• Effect on intestinal flora: prebiotic role
• Effects on intestinal infections and mineral absorption
• Effect on the immune system and other physiological effects
• Analytical methods

• The production of dairy products using LAB
• Dairy products with probiotic LAB
• The health benefits of probiotic LAB<
• Enhancing the viability and stability of LAB
• Enhancing the functionality of LAB

• Natural sources of CLA
• Commercial production of CLA
• Analytical methods
• The influence of processing on the CLA content of dairy products
• Functional benefits of CLA: cancer
• Multisite anticarcinogenesis
• Multistage anticarcinogenesis
• Mechanisms of CLA anticarcinogenesis
• Functional benefits of CLA: lipid and protein metabolism
• The process of CLA metabolism
• Functional benefits of CLA: atherosclerosis
• Functional benefits of CLA: immune function
• Functional benefits of CLA: diabetes

Chapter 12: Enhancing the functionality of prebiotics and probiotics

• The functional enhancement of prebiotics
• Targeted prebiotics
• Current manufacturing technologies for prebiotics
• Emerging manufacturing technologies for second generation prebiotics
• The functional enhancement of probiotics

• Key safety issues
• Identifying probiotic strains
• Potential risk factors: acute toxicity
• Potential risk factors: microbial metabolism
• Potential risk factors: microbial properties and binding
• Other potential risk factors
• Post-marketing surveillance
• Safety issues for new generation probiotics
• The safety of animal probiotics
• The current regulatory context

• Setting up a clinical trial: protocols
• Statistical analysis
• Ethical issues
• Managing a clinical trial
• Assessing the validity of a clinical trial

• The role of health in food choice
• Nutritional guidelines and health claims
• Consumers, health claims and products
• Consumer attitudes to functional foods

• Research projects within the PROEUHEALTH cluster
• Developing research tools: MICROBE DIAGNOSTICS
• Understanding mechanisms of action: DEPROHEALTH, PROPATH and EU MICROFUNCTION
• Investigating effects on health: PROGID, CROWNALIFE and PROSAFE
• Probiotic and prebiotic technologies: PROTECH
• Consumers and the perceived health benefits of probiotics

• Drivers of the functional foods market
• The growth of the functional foods market in the US
• The regulatory context in the US
• The potential for functional dairy foods in the US