Mass Spectrometry book from C.H.I.P.S.

Fundamentals of Contemporary Mass Spectrometry
by Chhabil Dass

Fundamentals of Contemporary Spectrometry gives readers a concise and authoritative overview of modern mass spectrometry instrumentation, techniques, and applications, including the latest developments.

Fundamentals of Contemporary Mass Spectrometry gives scientists in diverse disciplines a practical foundation in modern mass spectrometry.



1. Basics of Mass Spectrometry

  • Brief History of Mass Spectrometry
  • Desirable Features of Mass Spectrometry
  • Basic Principles of Mass Spectrometry
  • Anatomy of a Mass Specturm

2. Modes of Ionization

  • Why Ionization in Required
  • General Construction of an Ion Source
  • Electron Ionization
  • Chemical Ionization

3. Mass Analysis and Ion Detection

  • Mass Resolving Power
  • Kinetic Energy of Ions
  • Magnetic-Sector Mass Spectrometers
  • Quadrupole Mass Spectrometers

4. Tandem Mass Spectrometry

  • Basic Principles of Tandem Mass Spectrometry
  • Types of Scan Functions
  • Ion Activation and Dissociation
  • Reactions in Tandem Mass Spectrometry

5. Hyphenated Separation Techniques

  • Benefits of Coupling Separation Devices with Mass Spectrometry
  • General Considerations
  • Chromatographic Properties
  • Gas Chromatography/Mass Spectrometry

Organic and Inorganic Mass Spectrometry

6. Organic Mass Spectrometry

  • Determination of Molecular Mass
  • Molecular Formula from Accurate Mass Values
  • Molecular Formula from Isotopic Peaks
  • General Guidelines for Interpretation of a Mass Spectrum

7. Inorganic Mass Spectrometry

  • Ionization of Inorganic Compounds
  • Thermal Ionization Mass Spectrometry
  • Spark-Source Mass Spectrometry
  • Glow Discharge Ionization Mass Spectrometry

8. Proteins and Peptides: Structure Determination

  • Structure of Proteins
  • Determination of the Sequence of a Protein
  • General Protocol for Amino Acid Sequence Determination of Proteins
  • Molecular Mass Measurement of Proteins

9. Proteins and Peptides: Posttranslational Modifications

  • Traditional Approaches to Identify Disulfide Bonds
  • Mass Spectrometry-Based Methods to Identify Disulfide Bonds
  • Labeling for the Analysis of Phosphoproteins
  • Mass Spectrometry Protocol for the Analysis of Phosphoproteins

10. Proteins and Peptides: Higher-Order Structures

  • Charge-State Distribution
  • Hydrogen-Deuterium Exchange to Study Conformational Stated of Proteins
  • Chemical Cross-Linking as a Probe for the Three-Dimensional Structure of Proteins
  • Ion Mobility Measurements to Study Protein Conformational Changes

11. Structural Diversity in Oligosaccharides

  • Classes of Glycans
  • Mass Spectrometric Methods for Complete Structure Elucidation of Oligosaccharides

12. Characterization of Lipids

  • Classification and Structures of Lipids
  • Mass Spectrometry of Fatty Acids and Acylglycerols
  • Mass Spectrometry of Phospholipids
  • Mass Spectrometry of Glycolipids

13. Structure Determination of Oligonucleotides

  • Structures of Nucleotides and Oligonucleotides
  • Mass Spectrometry Analysis of Nucleosides and Nucleotides
  • Cleavage of Oligonucleotides
  • Molecular Mass Determination of Oligonucleotides

14. Quantitative Analysis

  • Advantages of Mass Spectrometry
  • Data Acquisition
  • Calibration
  • Validation of a Quantitative Method

15. Miscellaneous Topics

  • Enzyme Kinetics
  • Imaging Mass Spectrometry
  • Analysis of Microorganisms
  • Clinical Mass Spectrometry


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Fundamentals of Contemporary Mass Spectrometry
by Chhabil Dass
2007 585 pages $117.95 + shipping
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