This book discusses key principles of particulate science and their practical applications.

Covers:

• particulate material, its form and production
• sampling from bodies of powder
• particle size descriptors and statistics
• behavior of particles
• instrumental analysis
• particle size measurement and synergy of adopted techniques
• physical behavior of a powder
• in vitro and in vivo performance criteria

Exploring the growth in knowledge of particle properties and the variety of technological advances in particle manufacture, A Guide to Pharmaceutical Particulate Science gives readers the tools they need to grasp the science and its use in the industry.

Features

• Highlights the appropriate means to use this science for the benefit of industry
• Provides a guide to key principles and their practical applications
• Addresses the potential for error, misuse or abuse of data
• Discusses particle characterization and its impact on regulatory submissions from formulation through toxicity and efficacy
• Covers the application of particulate science in the formulation design, manufacturing, and control of medicines

Contents

1. INTRODUCTION AND OVERVIEW
   • Situation Analysis
   • Quality of Published Data on Particle Size in Pharmaceuticals
   • The Future of Crystal Engineering
   • Chemistry and Pharmacy Regulatory Submissions
   • Misconceptions and Misunderstandings of Particulate Science
   • Powerful Methods Complementary to Particle Sizing
   • Integration of Particle Sizing Methods with their In-Use Situation
   • Adjacencies and Interactions Between Particles
   • Lessons from Other Industries
   • Pharmaceutical Particulate Science as a Core Educational Requirement
   • Particle Characterization and its Impact on Regulatory Submissions from Formulation through Toxicology and Efficacy

2. PARTICULATE SYSTEMS: MANUFACTURE AND CHARACTERIZATION
   • States of Matter
   • Crystalline Solids
   • Crystal Symmetry
   • Euler's Relationship
   • Crystal Systems
   • Miller Indices
   • Space Lattices
   • Solid State Bonding
   • Isomorphs and Polymorphs
   • Enantiomorphs and Racemates
   • Crystal Habit
   • Crystal Imperfections
   • Methods of Particulate Production
   • Particulate Systems

3. SAMPLING AND MEASUREMENT BIASES
   • Sampling Strategies
   • Statistical Analyses
   • Sampling Techniques
   • Segregation
   • Sampling
   • Sampling Errors
   • Preparation Errors
   • Particle Size Measurements Errors

4. PARTICLE SIZE DESCRIPTIONS AND STATISTICS
   • Particle Size Descriptions
   • Particle Size Statistics
   • Mathematical Distributions
   • Applications

5. BEHAVIOR OF PARTICLES
   • Physical Properties
   • Particle Adhesion
   • Particle Motion in Bulk Powders
   • Particle Motion in Gaseous Dispersions
   • Particle Motion in Liquid Media

6. INSTRUMENTAL ANALYSIS
   • Direct Imaging
   • Indirect Imaging
   • Physical Methods of Particle Size Separation
   • Approaches to Calibration

7. METHODS OF PARTICLE SIZE MEASUREMENT AND THEIR IMPORTANCE FOR SPECIFIC APPLICATIONS (INSTRUMENT SYNERGY)
   • An Essay on Measures of Diameters

8. PARTICLE SIZE BEHAVIOR AND PHYSICAL BEHAVIOR OF A POWDER
   • Selection of the Appropriate Particle Size Expression
   • Powder Flow and Mixing
   • Dispersion
   • Granulation and Compression

9. CLINICAL EFFECT OF PHARMACEUTICAL PARTICULATE SYSTEMS
   • Oral Delivery
   • Parenteral Delivery
   • Respiratory Delivery
   • Nasal Delivery
   • Transdermal and Topical Delivery
   • Ocular Delivery
   • Otic Delivery
   • Buccal and Sublingual Delivery
   • Rectal Delivery
   • Vaginal Delivery

References
Index

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