Genetics of Asthma and Chronic Obstructive Pulmonary Disease provides an in-depth overview of current thought on the genetics and genomics of asthma and COPD in relation to their pathogenesis and treatment.

Features:

• Includes chapters on genetic epidemiology, techniques in statistical analysis, and the use of animal models for the study of airway disease genetics
• Presents the results of recent linkage and association studies and epigenetic and environmental influences, and considers their impact on the future management of asthma and COPD
• Considers the development of proteomic strategies to possibly detect relevant proteins in disease development and progression
• Weighs the possibility that both asthma and COPD have common genetic origins and may represent different expressions of a similar disease process

Contents

1. Introduction to Genetics
2. Genetic Epidemiology of Reduced Lung Function
3. Gene-Environment Interaction in Asthma
4. Epistatic Interaction, Age and Gender Effects
5. Microarray Techniques and Data in Asthma/COPD
6. Mouse Models for Asthma and Mouse Asthma Genetics
7. Knock out Models for Asthma
8. Comparative Genomics of Asthma.
9. Proteomic Techniques for Asthma and COPD Research
10. Linkage to Asthma and Its Intermediate Phenotypes
11. Linkage Analysis of Spirometric Phenotypes and COP
12. Fine Mapping and Whole Genome Association Studies in Asthma and COPD
13. Association Studies in Asthma
14. Association Studies in COPD
15. b-Adrenergic Receptor. IL13
16. CD14 and Toll-like Receptors
17. Pharmacogenetics

Index

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