Genetic Hearing Loss describes the normal development of the ear, updates the classification and epidemiology of hearing loss, and surveys the usage of audiometric tests and diagnostic medical examinations.

Features:

• Describes the normal development of the ear
• Updates the classification and epidemiology of hearing loss
• Surveys the usage of audiometric tests and diagnostic medical examinations
• Illuminates the most important syndromes associated with hearing loss such as Usher, Pendred, and Waardenburg syndromes
• Discusses the maternal inheritance patterns of mitochondrial hearing loss
• Provides a roadmap to gene localization and isolation in nonsyndromic hearing loss, exploring connexins, tectorins, myosins, ion channels, and other disease genes
• Highlights otosclerosis, one of the most common types of hearing loss
• Considers mechanisms regulating hair cell differentiation and regeneration
• Elucidates the future of genetic testing for hearing loss

Contents

Hearing and Hearing Loss

• Normal Development of Ear in the Human and Mouse
• Audiometric Test and Diagnostic Workup
• Classifation and Epidemiology

Syndromic Hearing Loss

• Usher Syndrome
• Pendred Syndrome
• Waardenburg Syndrome
• Jervell and Lange-Nielsen Syndrome
• HDR Syndrome
• Branchio-oto-renal Syndrome
• Treacher Collins Syndrome
• MYH9
• Mitochondrial Hearing Loss

Genes Responsible for Nonsyndromic Hearing Loss

• Gene Localization and Isolation in Nonsyndromic Hearing Loss
• Connexins
• Myosin VI
• K-Channel Gene KCNQ4
• COL11A2
• Pou-Domain Transcription Factors
• Tectorin
• EYA4
• DFNA5
• COCH
• Diaphanous
• Claudin 14
• CDH23
• TMPRSS3
• Otosclerosis

Miscellaneous Factors

• Mechanisms That Regulate Your Cell Differentiation and Regeneration
• Genetic Testing: Possibilites and Attitudes

Index

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