Gene Therapy for Neurological Disorders supplies the most recent advances, studies, and expert opinion on gene therapy for neurological disorders.

Features:

• Explores the applications, advantages, and limitations of the major gene therapy vectors including adenovirus, AAV, lentivirus, HSV, and non-viral vector systems
• Analyzes the brain immune response to gene therapy vectors using cutting-edge technologies
• Provides thorough analyses of human clinical trial results for several vector systems and approaches
• Covers major neurological disorders including Parkinson's disease, Alzheimer's disease, multiple sclerosis, chronic pain, and brain cancer

Contents

1. Immune Responses to Viral Vectors: Implications for Neurological Gene Therapy
2. Gene Transfer to the Nerve System Using HSV-1-Derived Amplicon Vectors
3. Adeno Associated Viral Vectors for the Nervous System
4. Heat Shock Proteins for Neurological Gene Therapy
5. iBAC Technologies for Neurological Disease
6. Targeted Gene Modification of the Nervous System
7. Astrocytes as Targets for Neurological Gene Therapy
8. Targeting Non-Viral Gene Transfer Vectors: What We Learn From Viruses & Other Pathogens
9. Gene Therapy Applications for Parkinson's Disease
10. HSV-Mediated Gene Transfer in the Treatment of Chronic Pain
11. Immunotherapeutic Approaches for Alzheimer's Disease
12. Gene Therapy of Multiple Sclerosis and in CNS Autoimmune Mouse Models
13. Novel Gene Therapeutic Approaches to Brain Cancer
14. Vaccines and Beneficial Immunity in Glioma Patients
15. Replicating Viruses for Brain Tumor Treatment
16. Adenovirus-mediated HSV-tk Gene Therapy for Malignant Glioma: Clinical Experience

Index

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