edited by Howard J. Allen and Edward C. Kisailus

This book highlights and speculates on design-order and structure-function correlates of glycoconjugates-integrating structural and biosynthetic data with the functional role of glycoconjugates.

Features

• Discusses current strategies to elucidating oligosaccharide structures and mechanisms of biosynthesis and turnover
• Presents the characteristics of macromolecules that interact with glycoconjugates
• Illustrates the specificity of recognition which cells have developed while using a relatively small array of monosaccharides
• Covers classical methodology of structural and biosynthetic analysis as well as new research in molecular biology of glycoconjugates
• Provides a guide to carbohydrate and glycoconjugate nomenclature
• Explores the role of model compounds in glycoconjugate chemistry and function
• And more!

Contents

1. Introduction to Glycoproteins
2. Nomenclature of Monosaccharides, Oligosaccharides, and Glycoconjugates
3. Methods of Carbohydrate Analysis and Structural Determination: Chemical and Enzymatic Methods
4. Nuclear Magnetic Resonance Approaches to Oligosaccharide Structure Elucidation
5. Mass Spectrometry of Carbohydrates
6. Synthetic Glycoconjugates
7. Proteoglycans: Structure, Synthesis, Function
8. Glycolipids: Structure, Synthesis, Functions
9. Biosynthesis of Serine (Threonine)-N-Acetylgalactosamine-Linked Carbohydrate Moieties
10. Synthesis of Asparagine-Linked Oligosaccharides: Pathways, Genetics, and Metabolic Regulation
11. Recent Advances in the Development of Potential Inhibitors of Glycosyltransferases
12. Function of Carbohydrate Moieties: Membrane and Nonsecretory Glycoproteins
13. Function of the Carbohydrate Moieties of Secretory Glycoconjugates
14. Mechanisms and Control of Glycoconjugate Turnover
15. Molecular Biology of Glycosyltransferases and Glycosidases
16. Plant Lectins: Molecular Biology, Synthesis, and Function
17. Microbial Lectins
18. Invertebrate Lectins: Distribution, Synthesis, Molecular Biology, and Function
19. ß-Galactoside-Binding Vertebrate Lectins: Synthesis, Molecular Biology, Function

Index

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