Glycogen Synthase Kinase 3 (GSK-3) and Its Inhibitors explores the nature of this promising enzyme, providing a thorough introduction and discussion, and mentions the birth of several chemical families of GSK-3 inhibitors with varying selectivity.

Features:

• Cellular functions
• Neuronal cell biology
• Crystal structures
• Kinase-kinase and site-site interactions in the phosphorylation of tau
• Therapeutic target in human pathology
• Role in stem cells
• Physiology studies
• Development and therapeutic potential of GSK-3 inhibitors

Contents

Cellular Functions of GSK-3

• Glycogen Synthase Kinase-3 - an Introductory Synopsis
• Glycogen-Synthase-Kinase-ß (GSK-3ß) a Key Signaling Enzyme: A Developmental Neurobiological Perspective
• Role of GSK3/Shaggy in neuronal cell biology
• The Crystal Structures of Glycogen Synthase Kinase 3
• Kinase-Kinase and Site-Site Interactions in the Phosphorylation of Tau by GSK-3

GSK3 as a Therapeutic Target in Human Pathology

• GSK-3, a Key Player in Alzheimer’s Disease
• Glycogen Synthase Kinase-3: A Target for Novel Mood Disorder Treatments
• GSK3 and Stem Cells
• Glycogen Synthase Kinase-3: role in Neurodegeneration and Neuroprotection
• Protein Kinase Inhibitors. Assay Development
• Animal Models with Modified Expression of GSK-3 for the Study of Its Physiology and of Its Implications in Human Pathologies

GSK-3 Inhibitors: Development and Therapeutic Potential

• Lithium, the Seminal GSK3 Inhibitor
• Inhibition of GSK3 as Therapeutic Strategy in Disease: Efficacy of AR-A014418
• TDZD’s: Selective And ATP Non Competitive Glycogen Synthase Kinase-3 Inhibitors
• 3-Amino Pyrazoles as Potent and Selective Glycogen Synthase (GSK-3) Inhibitors
• Marine compounds as a new source for Glycogen Synthase Kinase-3 Inhibitors

Index

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