Gene Therapy of Autoimmune Diseases discusses the most promising avenues in this exciting new field.
Contents
1. Gene Therapy Approaches for Autoimmune Diseases of the Central Nervous System and Other Tissues
- Gene Therapy of Autoimmune Disorders
- Cytokines, Chemokines and Cytokine Receptors
- Molecules Modulating Apoptosis
- Antigen-Based Therapy
- Tissue Repair and Replacement
2. Gene Therapeutics in Autoimmune Diabetes
- Overview of Therapeutics Challenges in Type 1 Diabetes Mellitus
- Therapeutic Options
- Prevention Strategies
3. Immunogene Therapy with Nonviral Vectors
- Nonviral Gene Therapy Vectors
- Optimizing Gene Transfer
- In Vivo Electroporation
- CpG Motifs and Toll-Like Receptor 9
- CpG ODNs as Immunotherapeutic Agents
- Detrimental Effects of Plasmid DNA or CpG ISS Motifs
- The Potent Inhibitory Effects of TGF-β1 and Its Use in Gene Therapy
- Cytokine Gene Therapy of Lupus
- Applicability of TGF-β1 Gene Therapy to Various Imflammatory Diseases
- Cytokine Gene Therapy of Organ-Specific Autoimmune Diseases
- IL-10 Gene Therapy for the Treatment of Inflammatory Diseases
- Cytokine Gene Therapy and the Iduction of Regulatory T Cells
- Retroviral Transduction of T Cells and Adoptive Cell Therapy of Autoimmune Disease
- Gene Therapy of Lupus with Cytokine Inhibitors
- Cytokine Inhibitors in Arthritis
- Cytokine Inhibitors in Other Autoimmune Diseases
- RNA Interference with Nonviral Vectors
- Nonviral Gene Transfer in Humans
4. Targeting Antigen-Specific T Cells for Gene Therapy of Autoimmune Disease
- Genetic Modification of T Cells
- Animal Studies: Therapeutif Products
- Animal Studies: Regenerative Products
- Animal Studies: Alternative of Cellular Interactions
5. Therapeutic Gene Transfer for Rheumatoid Arthritis
- Vectors for Gene Therapy of RA
- Immunogenicity Induced by Gene Therapy Vectors
- What Are the Best Candidate Genes for Gene Therapy in RA?
- How to Choose Between Local and Systemic Treatment?
- How to Choose Between in Vivo and ex Vivo Strategies?
- From Preclinical Experiments to Clinical Trials
6. Gene Therapy-Based Approach for Immune Tolerance Induction Using Recombinant Immunoglobulin Carriers
- Hapten-Carriers in the History of Tolerance
- Gene Transfer of IgG-Peptides
- Mechanisms of Action
- Applications for Clinical Models of Autoimmune Diseases
7. DNA Vaccination Against Autoimmune Diseases
- DNA Vaccination
- EAE
- Autoimmune Diabetes
- DNA Vaccination Against Arthritis
Index
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