Handbook of Antioxidants provides an authoritative treatment on the chemical, biological, and clinical aspects of antioxidant molecules—discussing the latest research findings and clinical trials on the protective role antioxidants play in preventing or minimizing free radical damage.

This volume contains new and expanded material on antioxidants in beverages and herbal products, nitric oxide and selenium, and the effect of vitamin C on cardiovascular disease and of lipoic acid on aging, hyperglycemia, and insulin resistance!

Offering over 4,200 contemporary references—2,000 more than the previous edition—this Second Edition is an up-to-the-minute source for nutritionists and dietitians, cell biologists and biochemists, cardiologists, oncologists, dermatologists, and medical students in these disciplines.

Contents

1. General Topics
   • Food-Derived Antioxidants: How to Evaluate Their Importance in Food and In Vivo
   • Measurement of Total Antioxidant Capacity in Nutritional and Clinical Studies
   • Quantification of Isoprostanes as Indicators of Oxidant Stress In Vivo

2. Vitamin E
   • Efficacy of Vitamin E in Human Health and Disease
   • Vitamin E Bioavailability, Biokinetics, and Metabolism
   • Biological Activity of Tocotrienols

3. Vitamin C
   • Vitamin C: From Molecular Mechanisms to Optimum Uptake
   • Vitamin C and Cardiovascular Diseases
   • Epidemiological and Clinical Aspects of Ascorbate and Cancer

4. Carotenoids
   • Carotenoids: Linking Chemistry, Absorption, and Metabolism to Potential Roles in Human Health and Disease
   • Antioxidant Effects of Carotenoids: Implication in Photoprotection in Humans
   • Oxidative Breakdown of Carotenoids and Biological Effects of Their Metabolites
   • Carotenoids in the Nutrition of Infants
   • Human Studies on Bioavailability and Serum Response of Carotenoids

5. Polyphenols and Flavonoids
   • Caffeic Acid and Related Antioxidant Compounds: Biochemical and Cellular Effects
   • Polyphenols and Flavonoids Protect LDL Against Atherogenic Modifications
   • Phytoestrogen Content in Foods and Their Role in Cancer
   • Peroxynitrite Scavenging by Mitochondrial Reductants and Plant Polyphenols

6. Antioxidants in Beverages and Herbal Products
   • Antioxidant and Other Properties of Green and Black Tea
   • The Phenolic Wine Antioxidants
   • French Maritime Pine Bark: Pycnogenol
   • Spices as Potent Antioxidants with Therapeutic Potential

7. Lipoic Acid and Glutathione
   • Lipoic Acid: Cellular Metabolism, Antioxidant Activity, and Clinical Relevance
   • Cellular Effects of Lipoic Acid and Its Role in Aging
   • Vascular Complications in Diabetes: Mechanisms and the Influence of Antioxidants
   • Therapeutic Effects of Lipoic Acid on Hyperglycemia and Insulin Resistance
   • Bioavailability of Glutathione

8. Melatonin
   • Antioxidant Capacity of Melatonin
   • Radical and Reactive Intermediate-Scavenging Properties of Melatonin in Pure Chemical Systems

9. Selenium
   • Selenium: An Antioxidant?
   • Selenium Status and Prevention of Chronic Diseases

10. Nitric Oxide
    • Antioxidant Properties of Nitric Oxide

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