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Drug Metabolism Handbook from C.H.I.P.S.

Handbook of Drug Metabolism
Second edition
edited by Paul G. Pearson

Handbook of Drug Metabolism provides comprehensive coverage of the fundamental aspects of drug metabolism and the practical applications that help guide researchers through key challenges in modern drug discovery and development.

This Second edition covers the many recent scientific and technical advances in the field and is organized into four sections:

  • fundamental aspects of drug metabolism
  • factors that affect drug metabolism
  • new enabling technologies to study drug metabolism
  • applications of metabolism studies in drug development and drug discovery

Contents

Part I: Fundamental Aspects of Drug Metabolism

  1. The Evolution of Drug Metabolism Research
  2. Pharmacokinetics of Drug Metabolites
  3. Hepatic Architecture: Functional and Subcellular Correlates
  4. The Cytochrome P450 Oxidative System
  5. Transformation Enzymes: Oxidative; Non-P450
  6. UDP-Glucuronosyltransferases

Part II: Factors Which Affect Drug Metabolism

  1. Pharmacogenetics
  2. Inhibition of Drug Metabolizing Enzymes
  3. The Ontogeny of Drug Metabolizing Enzymes/Pediatric Exclusivity
  4. Sites of Extra Hepatic Metabolism, Part I: Lung
  5. Sites of Extra Hepatic Metabolism, Part II: Gut
  6. Sites of Extra Hepatic Metabolism, Part III: Kidney
  7. Sites of Extra Hepatic Metabolism, Part IV: Brain

Part III: Technologies to Study Drug Metabolism

  1. LC-MS Analysis in Drug Metabolism Studies
  2. The Practice of NMR Spectroscopy in Drug Metabolism Studies
  3. Applications of Recombinant and Purified Human Drug-Metabolizing Enzymes: An Industrial Perspective
  4. In Vitro Metabolism: Subcellular Fractions
  5. In Vitro Metabolism: Hepatocytes
  6. Drug Interaction Studies in the Drug Development Process: Studies In Vitro
  7. Enzyme Induction Studies in Drug Discovery & Development
  8. Experimental Characterization of Cytochrome P450 Mechanism Based Inhibition

Part IV: Applications of Metabolism Studies in Drug Discovery and Development

  1. Clinical Drug Metabolism
  2. Minimizing Metabolic Activation in Drug Discovery
  3. Kinetic Differences between Generated and Preformed Metabolites: A Dilemma in Risk Assessment
  4. The Use of Transgenic Animals to Study Drug Metabolism
  5. Preclinical Pharmacokinetic Models for Drug Discovery and Development

Index

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Handbook of Drug Metabolism
Second edition
edited by Paul G. Pearson

2008 616 pages $308.95 + shipping
Texas residents please add 6.75 % sales tax

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