Second Edition
by Johannse Ring
Handbook of Atopic Eczema comprises the state of the art in pathophysiology, clinical medicine, and therapeutic management and demonstrates that there is no cream, pill, or diet for this disease, but that a disturbed barrier function can only be repaired by adequate and individualized skin care.
Handbook of Atopic Eczema also shows how unspecific anti-inflammatory treatment has to be individually tailored according to body area affected, patient age, and severity of skin lesions.
Contents
Clinical Aspects of Atopic Eczema
- Atopy: Condition, Disease, or Syndrome?
- History
- Clinical Symptoms
- Etiopathophysiological Aspects
- The History of Atopic Eczema/Dermatitis
- Precursors of Atopic Eczema
- Toward a Modern Definition
- Historical Landmarks in the Modern History
of Atopic Eczema
- The History of Atopic Eczema Treatments
- What History Tells Us Today
- Epidemiology of Atopic Eczema
- Diagnostic Criteria
- Assessment in Epidemiological Studies
- Measures of Frequency
- Trends and Frequency of Atopic Eczema
- Atopic Eczema in East andWest Germany
- The Burden of Atopic Eczema
- Nature of the Burden
- Measurement of Burden
- Strategies for Improving Burden
- Declaration of Interest
- Clinical Symptoms of Atopic Eczema
- Evolution of Atopic Eczema
- Course of Atopic Eczema
- Some Typical Clinical Features
- Atopic Eczema in the Adult Patient
- The Prognosis of Atopic Eczema
- Atopic Eczema in Infants
- Infantile Eczema: What It Is and What It Is Not
- Historical Background: Hall’s Thesis (1905)
- Review of Current Diagnostic Criteria
- Time Course of Clinical Aspects in Infancy
- Differential Diagnosis
- Stigmata of the Atopic Constitution
- Features of Atopy
- Constitutional Stigmata of Atopy
- Constitutional Stigmata as Markers of Atopy
...and chapters 8-22
Pathophysiology of Atopic Eczema
- Clinical Genetics of Atopic Eczema
- Methods for Mapping Complex Diseases
- Atopic Eczema/Dermatitis Syndrome
- Linkage Studies
- Statistics of Linkage Analysis
- Candidate Gene
- The Molecular Genetics of Atopy
- Candidate Genes
- Genome Screens
- Single Gene Disorders
- Maternal Effects
- Genetics of Atopic Eczema
- Genetic Epidemiology
- Approaches to the Genetic Analysis
of Atopic Eczema
- Mechanisms of IgE-Regulation
- Mechanisms of Allergic Sensitization:
Allergen Uptake, Processing, and
Presentation
- Activation, Migration, and Maturation
of Antigen-Presenting Cells
- T Cell Activation and Polarization of the
T Cell Response
- Origin and Maturation of B Cells
- Immunoglobulins
- Dendritic Cells in Atopic Eczema
- Antigen-Presenting Cell Subpopulations
in Atopic Eczema Skin
- Types of Antigen-Presenting Cells in
Peripheral Blood
- IgE-Facilitated Amplification of the
Immune Response
- Role of Dendritic Cells in Initiating,
Maintaining, and/or Silencing the Allergic
Tissue Inflammation
- Effects of Topical Calcineurin Inhibitors
- Inflammatory Dendritic Epidermal Cells
- Langerhans Cells
- Inflammatory Dendritic Epidermal Cells
- Delineation of Inflammatory Dendritic
Epidermal Cells from Langerhans Cells
- Ontogenesis of Inflammatory Dendritic
Epidermal Cells
- Inflammatory Dendritic Epidermal Cells
Are Present in Early Atopic Eczema
Lesions
...and chapters 29-45
Management of Patients with Atopy Eczema
- Primary Prevention of Atopy
- The Natural History of Atopic
Manifestations
- Hereditary Factors
- Nongenetic Factors
- The Domestic Environment
- Possible Consequences for Prevention
- Role of Allergy Testing in Atopic Eczema
- Food Allergy in Atopic Eczema
- Practical Approach to the Patient with
Suspected Food Allergy and AE
- Aeroallergens and Atopic Eczema
- Atopy Patch Test with Aeroallergens
- Probiotics in Atopic Eczema
- The HygieneHypothesis
- Primary Prevention Strategies in Atopic
Eczema
- Probiotics for Primary Prevention
inHigh-Risk Families
- Measuring Disturbed Barrier Function
in Atopic Eczema
- TransepidermalWater Loss (TEWL)
- SkinHydration and TEWL
- Skin Lipids and TEWL
- Reactivity to Irritants
- Barrier Function in Atopic Patients
Without Dermatitis
- TEWL and Topical Agents for Atopic
Eczema
- Basic Topical Therapy with Emollients
in Atopic Eczema
- Amphiphilic Systems
- Hydrophilic Systems
- Desired Vehicle Effects: Hydration of the
Stratum Corneum and Induction of a
Diffusion Barrier Against Hydrophilic
Irritants
- Modulation of Vehicle Effects by Glycerol
or Urea
- Vehicle Influence upon Biologic Effect of
Topically Applied Drugs
- Syndets in the Treatment of Atopic Eczema
- Cleansing of Eczematous Skin – The Scope
of the Problem
- The Development of Synthetic Detergents –
A Real Option
- Desirable and Undesirable Effects of
Syndets on Human Skin – the Role of pH
- Syndets and Eczematous Skin – Clinical Assessement
...and chapters 52-66
Index
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